{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:50:14Z","timestamp":1785412214524,"version":"3.56.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25103802_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to evaluate the impact of transitioning from a conventional antimicrobial stewardship team (AST) to an interdisciplinary infectious disease support team (IDST) on patient mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103802_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Single-center retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103802_as3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Yamanashi Prefectural Central Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103802_as4\">\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>We included patients with bacteremia during the AST and IDST periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103802_as5\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We implemented an interdisciplinary IDST that provided comprehensive support beyond antimicrobial selection and treatment. We compared 28-day mortality outcomes in hospitalized patients with bacteremia during the AST-only period (April 2021\u2013March 2022) and the IDST-intervention period (April 2022\u2013March 2023). Cox proportional hazards modeling was used to assess 28-day mortality; multivariable logistic regression served as a prespecified sensitivity analysis. Between-group differences were tested using two-sided tests (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05), and 95% confidence intervals (CIs) were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103802_as6\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 854 patients (413 in the AST group and 441 in the IDST group), AST interventions did not significantly decrease 28-day mortality compared with no-intervention cases (20.8% vs 23.3%,\n                      <jats:italic>P<\/jats:italic>\n                      = .630). However, intervention by the IDST significantly reduced 28-day mortality compared with the no-IDST group (16.1% vs 25.2%,\n                      <jats:italic>P<\/jats:italic>\n                      = .019). In the multivariate Cox proportional hazards model, IDST interventions remained independently associated with a reduced 28-day mortality (hazard ratio, 0.518; 95% CI, 0.325\u20130.826;\n                      <jats:italic>P<\/jats:italic>\n                      = .006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103802_as7\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Transitioning from an AST to an interdisciplinary IDST model was associated with lower 28-day mortality in bacteremia cases, possibly due to sustained diagnostic and therapeutic interventions. Our findings support stewardship as a team-based process and may significantly impact patient outcomes by maintaining involvement until treatment completion and clinical stabilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10380","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:47:07Z","timestamp":1768812427000},"page":"295-304","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["An interdisciplinary infectious disease support team with longitudinal process interventions is associated with lower 28-day mortality in bacteremia: a single-center cohort study"],"prefix":"10.1017","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-8433","authenticated-orcid":false,"given":"Aiju","family":"Endo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05r286q94","id-type":"ROR","asserted-by":"publisher"}],"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mikawa","sequence":"additional","affiliation":[{"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Ishibe","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05r286q94","id-type":"ROR","asserted-by":"publisher"}],"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Nakane","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05r286q94","id-type":"ROR","asserted-by":"publisher"}],"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Asakawa","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05r286q94","id-type":"ROR","asserted-by":"publisher"}],"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kido","sequence":"additional","affiliation":[{"name":"Ehime Prefectural Minamiuwa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Kameda Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Takatori","sequence":"additional","affiliation":[{"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Natsume","sequence":"additional","affiliation":[{"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Matsumoto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05r286q94","id-type":"ROR","asserted-by":"publisher"}],"name":"Yamanashi Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Hanawa","sequence":"additional","affiliation":[{"name":"Tokyo University of Science"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"S0899823X25103802_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001067"},{"key":"S0899823X25103802_ref13","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2017.6849"},{"key":"S0899823X25103802_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2015.10.006"},{"key":"S0899823X25103802_ref35","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"key":"S0899823X25103802_ref33","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.21048"},{"key":"S0899823X25103802_ref25","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"S0899823X25103802_ref36","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2001.tb143562.x"},{"key":"S0899823X25103802_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.49353"},{"key":"S0899823X25103802_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106611"},{"key":"S0899823X25103802_ref5","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S290835"},{"key":"S0899823X25103802_ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03736-w"},{"key":"S0899823X25103802_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2021.12.011"},{"key":"S0899823X25103802_ref1","unstructured":"1. 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