{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:55:40Z","timestamp":1785434140180,"version":"3.56.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25103887_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      This study aims to evaluate the effectiveness of an adapted methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA) decolonization program in an infirmary unit in Hong Kong that was inspired by successful interventions implemented in Orange County, California.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103887_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nasal, skin, and rectal swabs were collected to assess MRSA colonization. Decolonization involved applying 10% povidone-iodine ointment to the anterior nares twice daily for five days every other week, along with twice weekly chlorhexidine gluconate (CHG) bathing for six months. Compliance with the application of povidone-iodine and CHG bathing techniques was monitored by measuring their respective levels in the anterior nares and on the skin. Air and environmental samples were collected and analyzed over time using linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103887_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 60 patients in the infirmary unit (78% baseline MRSA carriers), overall MRSA colonization declined during the program, driven by significant reductions in skin colonization (65% to 29%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Environmental contamination on high-touch patient-care equipment (bathing trolleys and slings) also significantly decreased over time (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). These reductions coincided with the high-quality implementation of decolonization, evidenced by stable iodophor detection in nares during application weeks and sustained chlorhexidine levels on the skin, detectable 24 hours after bathing. In contrast, MRSA detection in air samples showed no significant change (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.096), possibly due to dispersal by persistent carriers during care activities even as skin and environmental contamination declined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25103887_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The adapted MRSA decolonization program was effective, significantly reducing overall MRSA colonization, especially at skin sites, while achieving high compliance with the protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.10388","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:59:48Z","timestamp":1769151588000},"page":"357-364","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Bridging borders: adapting the Orange County methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>\n                    decolonization protocol for an infirmary unit in Hong Kong"],"prefix":"10.1017","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-1932","authenticated-orcid":false,"given":"Shuk-Ching","family":"Wong","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xkx3e48","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region"},{"id":[{"id":"https:\/\/ror.org\/02zhqgq86","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of Hong 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Kwan-Yeung","family":"Chiu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zhqgq86","id-type":"ROR","asserted-by":"publisher"}],"name":"Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region"},{"id":[{"id":"https:\/\/ror.org\/02xkx3e48","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen Mary Hospital, Hong Kong Special Administrative Region"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-3943","authenticated-orcid":false,"given":"Kelvin Hei-Yeung","family":"Chiu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zhqgq86","id-type":"ROR","asserted-by":"publisher"}],"name":"Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region"},{"id":[{"id":"https:\/\/ror.org\/02xkx3e48","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen Mary Hospital, Hong Kong Special 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Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}