{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:18:33Z","timestamp":1788999513653,"version":"build-2803163510"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25000352_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To retrospectively observe procalcitonin (PCT) and antibiotic ordering practices in patients hospitalized with community-acquired pneumonia (CAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000352_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective, exact matched, multicenter cohort study from October 1, 2018 \u2013 March 31, 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000352_as3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>All hospitals across the Mayo Clinic Enterprise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000352_as4\">\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>Adult patients with CAP, identified using pneumonia diagnosis codes and receipt of systemic antibiotics with an indication of \u201crespiratory tract infection\u201d within 48 hours of hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000352_as5\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PCT testing within the first 7 days of hospitalization was compared to non-PCT care (nPCT). The primary outcomes were treatment duration, antibiotic days of therapy (DOT), and length of stay (LOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000352_as6\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      15364 patients met inclusion criteria. PCT testing occurred in 42.4% (6515\/15364) of encounters, totaling 8214 PCT results. 12880 unique patient encounters were matched 1:1, 6440 in each group. Treatment duration was longer in the PCT group compared to the nPCT group (5.1 vs 4.6 days, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Patients in the PCT group also received more DOT (8.6 vs 7.6 DOT,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and had a longer LOS (6.8 vs 5.9 days,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), respectively. There was no difference in 30-day all-cause mortality or\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection between groups. In a sensitivity analysis of nPCT patients compared to those with a peak value &lt;0.25 ng\/mL (i.e. normal result) there was no difference in treatment duration (4.6 days nPCT vs 4.7 days normal PCT,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.104) or LOS (5.9 days nPCT vs 6.0 days normal PCT,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.134).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000352_as7\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PCT testing in patients hospitalized with CAP was not associated with reduced antimicrobial utilization, LOS, or 30-day all-cause mortality.<\/jats:p>\n                  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