{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:58:37Z","timestamp":1792871917524,"version":"4.5.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X25000066_as1\"><jats:title>Objective:<\/jats:title><jats:p>To enumerate and describe the effect of whole genome sequencing (WGS) on epidemiological investigations of healthcare-associated transmission of nontuberculous mycobacteria (NTM).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X25000066_as2\"><jats:title>Design:<\/jats:title><jats:p>Systematic review.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X25000066_as3\"><jats:title>Methods:<\/jats:title><jats:p>We performed a literature search using targeted search terms to identify articles meeting inclusion criteria. Data extraction of study characteristics and outcomes was performed by two independent researchers. The primary outcome was the author interpretation of WGS utility in the investigation of suspected healthcare-associated transmission of NTM. The secondary outcome was whether a transmission route was identified through WGS.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X25000066_as4\"><jats:title>Results:<\/jats:title><jats:p>Thirty-one studies were included in the final analysis with 28 (90%) concluding that WGS was helpful in transmission investigations and in 19 of these 28 (68%) WGS aided in identifying a transmission route. The most common identified transmission routes were water-borne point sources (10), heater-cooler units (6), patient-to-patient (4), and a healthcare worker (1).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X25000066_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>WGS is an informative tool in investigating healthcare transmission of NTM.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ice.2025.6","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T06:39:26Z","timestamp":1738564766000},"page":"404-409","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Identifying healthcare transmission routes of nontuberculous mycobacteria with whole genome sequencing: a systematic review"],"prefix":"10.1017","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1937-0182","authenticated-orcid":false,"given":"Spencer 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M.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"S0899823X25000066_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2021.396"},{"key":"S0899823X25000066_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00128-2"},{"key":"S0899823X25000066_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"S0899823X25000066_ref36","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202209-779OC"},{"key":"S0899823X25000066_ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236533"},{"key":"S0899823X25000066_ref2","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2016.79.2.74"},{"key":"S0899823X25000066_ref31","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04908-22"},{"key":"S0899823X25000066_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60632-7"},{"key":"S0899823X25000066_ref22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202108-1911OC"},{"key":"S0899823X25000066_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw754"},{"key":"S0899823X25000066_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.02.011"},{"key":"S0899823X25000066_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2023.100397"},{"key":"S0899823X25000066_ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-017-0570-0"},{"key":"S0899823X25000066_ref32","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2022.263"},{"key":"S0899823X25000066_ref12","doi-asserted-by":"publisher","DOI":"10.3201\/eid2503.181282"},{"key":"S0899823X25000066_ref38","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0279"},{"key":"S0899823X25000066_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab192"},{"key":"S0899823X25000066_ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-024-00836-w"},{"key":"S0899823X25000066_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu967"},{"key":"S0899823X25000066_ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00243"},{"key":"S0899823X25000066_ref28","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01714-22"},{"key":"S0899823X25000066_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2023.05.013"},{"key":"S0899823X25000066_ref23","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00097-22"},{"key":"S0899823X25000066_ref27","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01547-21"},{"key":"S0899823X25000066_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2021.04.028"},{"key":"S0899823X25000066_ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25484-9"},{"key":"S0899823X25000066_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2022.06.013"},{"key":"S0899823X25000066_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239273"},{"key":"S0899823X25000066_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.261"},{"key":"S0899823X25000066_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz526"},{"key":"S0899823X25000066_ref30","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.68"},{"key":"S0899823X25000066_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.06.026"},{"key":"S0899823X25000066_ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19666-8"},{"key":"S0899823X25000066_ref11","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000111"},{"key":"S0899823X25000066_ref35","doi-asserted-by":"publisher","DOI":"10.7326\/M22-3306"},{"key":"S0899823X25000066_ref18","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01813-20"},{"key":"S0899823X25000066_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1120"},{"key":"S0899823X25000066_ref25","doi-asserted-by":"publisher","DOI":"10.3201\/eid2803.211791"},{"key":"S0899823X25000066_ref1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TNMI7-0024-2016"},{"key":"S0899823X25000066_ref42","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202009-1214OC"},{"key":"S0899823X25000066_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab946"},{"key":"S0899823X25000066_ref9","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.46.30396"}],"container-title":["Infection 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2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}