{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:58:04Z","timestamp":1775800684071,"version":"3.50.1"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X25000649_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Patients with Opioid Use Disorder (OUD) are prone to Multidrug-Resistant Organism (MDRO) colonization and infections, thus at risk for worse outcomes during critical illness. Understanding the prevalence and predictors of MDRO infections is essential to optimize interventions and treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000649_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000649_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study evaluated the prevalence of MDRO isolation among adults with OUD admitted to an intensive care unit (ICU) between January 1, 2018, and July 31, 2023. It included adults admitted to an ICU with bacterial infections and positive cultures obtained within 48 hours of admission. Demographics, clinical traits, and MDRO isolation rates were analyzed using descriptive statistics, univariate methods, and Least Absolute Shrinkage and Selection Operator (LASSO) regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000649_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      MDRO isolation occurred in 178 of 790 patients (22.5%), with methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      as the most frequently isolated organism. LASSO regression identified housing insecurity (OR: 1.79, 95% CI 1.09\u20132.93,\n                      <jats:italic>P<\/jats:italic>\n                      = .022), no receipt of medications for OUD treatment (OR: 1.56, 95% CI 1.06\u20132.29,\n                      <jats:italic>P<\/jats:italic>\n                      = .023), positive hepatitis C virus (HCV) status (OR: 2.19, 95% CI 1.19\u20134.03,\n                      <jats:italic>P<\/jats:italic>\n                      = .012), and intravenous antibiotic use in the prior 90 days (OR: 1.04 per 24 h, 95% CI 1.01\u20131.07,\n                      <jats:italic>P<\/jats:italic>\n                      = .007) as significant predictors of MDRO isolation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X25000649_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study highlights a high prevalence of MDRO isolation in critically ill OUD patients admitted for infection-related issues with positive cultures obtained within 48 hours of admission, influenced by factors like housing insecurity, no receipt of medications for OUD treatment, HCV status, and prior antibiotic use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2025.64","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:18:01Z","timestamp":1743736681000},"page":"604-610","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and predictors of multidrug resistant organism infections in critically ill patients with opioid use disorder: a multicenter retrospective cohort study"],"prefix":"10.1017","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4936-9775","authenticated-orcid":false,"given":"Zeeshan M.","family":"Rizwan","sequence":"first","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-8304","authenticated-orcid":false,"given":"Haris","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9570-6492","authenticated-orcid":false,"given":"Julie L.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-0191","authenticated-orcid":false,"given":"Kristin C.","family":"Cole","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-4498","authenticated-orcid":false,"given":"John C.","family":"O\u2019Horo","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ognjen","family":"Gajic","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-6689","authenticated-orcid":false,"given":"Ryan W.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"S0899823X25000649_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"S0899823X25000649_ref1","unstructured":"1. Centers for Disease Control Prevention. Antibiotic Resistance Threats in the United States. https:\/\/www.cdc.gov\/DrugResistance\/Biggest-Threats.html. Published 2019. Accessed June 21, 2023."},{"key":"S0899823X25000649_ref2","unstructured":"2. Centers for Disease Control Prevention. Wide-ranging online data for epidemiologic research (WONDER). http:\/\/wonder.cdc.gov. Published 2021. Accessed June 21, 2023."},{"key":"S0899823X25000649_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61132-6"},{"key":"S0899823X25000649_ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0273369"},{"key":"S0899823X25000649_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/2050312118784311"},{"key":"S0899823X25000649_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30297"},{"key":"S0899823X25000649_ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02950-8"},{"key":"S0899823X25000649_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20622"},{"key":"S0899823X25000649_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-020-00726-5"},{"key":"S0899823X25000649_ref25","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2020-216029"},{"key":"S0899823X25000649_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001071"},{"key":"S0899823X25000649_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5784"},{"key":"S0899823X25000649_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfaa150"},{"key":"S0899823X25000649_ref5","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2020\/e1554"},{"key":"S0899823X25000649_ref7","doi-asserted-by":"publisher","DOI":"10.3201\/eid2908.230323"},{"key":"S0899823X25000649_ref11","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S388680"},{"key":"S0899823X25000649_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab696"},{"key":"S0899823X25000649_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000928"},{"key":"S0899823X25000649_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac352"},{"key":"S0899823X25000649_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101938"},{"key":"S0899823X25000649_ref12","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.234"},{"key":"S0899823X25000649_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.2640"},{"key":"S0899823X25000649_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-116"},{"key":"S0899823X25000649_ref28","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001090"},{"key":"S0899823X25000649_ref9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02582-14"},{"key":"S0899823X25000649_ref16","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.01.25"},{"key":"S0899823X25000649_ref26","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S359157"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X25000649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:06:26Z","timestamp":1775797586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X25000649\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0899823X25000649"],"URL":"https:\/\/doi.org\/10.1017\/ice.2025.64","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}