{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:07:22Z","timestamp":1785431242934,"version":"3.56.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X26103973_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early identification of patients colonized with multidrug-resistant organisms (MDROs) facilitates infection control interventions. We assessed a Public Health Risk Model\u2019s ability to predict carbapenem-resistant Enterobacterales and other MDROs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26103973_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analyzed a medical intensive care unit patient cohort screened at time of admission for MDRO carriage (1\/2017\u20131\/2018). Encounters were linked to Illinois Hospital Discharge Data and assigned a public health risk model probability score. We compared the model\u2019s performance to traditional screening strategies that use variables locally available to clinicians at time of admission (i.e., transfer from other hospital, tracheostomy, gastrostomy, pressure ulcer). Model discrimination was evaluated by quantifying the area under the curve (AUC). For each approach, we assessed sensitivity, specificity, and number needed to screen (NNS) to detect one MDRO carrier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26103973_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Model probability calculation was successful in 1237\/1250 (98.9%) admissions. The model identified carbapenem-resistant Enterobacterales colonization well (AUC 0.82) and generalized to predict colonization with other healthcare-associated MDROs, including carbapenem-resistant\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (AUC 0.82) and vancomycin-resistant enterococci (AUC 0.76). The model did not predict MDROs with known local community reservoirs, i.e., third-generation cephalosporin-resistant Enterobacterales (AUC 0.61) and methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (AUC 0.59). At the same NNS, the model had higher sensitivity compared to use of traditional screening strategies (68% versus 41%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26103973_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A risk model using patient-level healthcare exposure data from a state public health dataset identified critically ill patients likely to harbor healthcare-associated MDROs at the time of admission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2026.10397","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:41:21Z","timestamp":1768977681000},"page":"272-276","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["A public health risk model using prior healthcare exposures identifies healthcare-associated pathogen carriage"],"prefix":"10.1017","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-8941","authenticated-orcid":false,"given":"Sarah E.","family":"Sansom","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01j7c0b24","id-type":"ROR","asserted-by":"publisher"}],"name":"Rush University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9282-4874","authenticated-orcid":false,"given":"Tanner","family":"Shull","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01j7c0b24","id-type":"ROR","asserted-by":"publisher"}],"name":"Rush University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-8501","authenticated-orcid":false,"given":"Mary K.","family":"Hayden","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01j7c0b24","id-type":"ROR","asserted-by":"publisher"}],"name":"Rush University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schoeny","sequence":"additional","affiliation":[{"name":"Rush University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9206-9579","authenticated-orcid":false,"given":"Angela","family":"Tang","sequence":"additional","affiliation":[{"name":"Illinois Department of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Vue","sequence":"additional","affiliation":[{"name":"Illinois Department of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh-Thu","family":"Runez","sequence":"additional","affiliation":[{"name":"Illinois Department of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Jovanov","sequence":"additional","affiliation":[{"name":"Illinois Department of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Trick","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01j7c0b24","id-type":"ROR","asserted-by":"publisher"}],"name":"Rush University"},{"name":"Cook County Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-6221","authenticated-orcid":false,"given":"Michael Y.","family":"Lin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01j7c0b24","id-type":"ROR","asserted-by":"publisher"}],"name":"Rush University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"S0899823X26103973_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2020.01.005"},{"key":"S0899823X26103973_ref3","first-page":"807","article-title":"Comparison of daily versus admission and discharge surveillance cultures for multidrug-resistant organism detection in an intensive care unit","volume":"230","author":"Sansom","year":"2024","journal-title":"J Infecti Diseases"},{"key":"S0899823X26103973_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00417-X"},{"key":"S0899823X26103973_ref12","first-page":"100310","article-title":"Risk factors of carbapenemase-producing Enterobacterales acquisition among adult intensive care unit patients at a Kentucky Academic Medical Center","volume":"5","author":"Wilson","year":"2023","journal-title":"IPIP"},{"key":"S0899823X26103973_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2018.150"},{"key":"S0899823X26103973_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2021.361"},{"key":"S0899823X26103973_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw461"},{"key":"S0899823X26103973_ref14","doi-asserted-by":"publisher","DOI":"10.1086\/668435"},{"key":"S0899823X26103973_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab457"},{"key":"S0899823X26103973_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2017.08.012"},{"key":"S0899823X26103973_ref8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-11-200206040-00013"},{"key":"S0899823X26103973_ref10","unstructured":"10. The Illinois Hospital Discharge Database. https:\/\/dph.illinois.gov\/topics-services\/prevention-wellness\/patient-safety-quality\/discharge-data.html. Accessed February 8, 2024."},{"key":"S0899823X26103973_ref11","doi-asserted-by":"publisher","DOI":"10.23889\/ijpds.v9i5.2852"},{"key":"S0899823X26103973_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit500"},{"key":"S0899823X26103973_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.42"},{"key":"S0899823X26103973_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2024.37"},{"key":"S0899823X26103973_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2012.11.008"},{"key":"S0899823X26103973_ref9","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","volume":"27","year":"2017"},{"key":"S0899823X26103973_ref23","unstructured":"23. XDRO Registry. https:\/\/xdro.dph.illinois.gov\/. Accessed January 9, 2025."},{"key":"S0899823X26103973_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz483"},{"key":"S0899823X26103973_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-023-01326-9"},{"key":"S0899823X26103973_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-023-01340-x"},{"key":"S0899823X26103973_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy091"},{"key":"S0899823X26103973_ref24","doi-asserted-by":"publisher","DOI":"10.1086\/338234"},{"key":"S0899823X26103973_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab109"},{"key":"S0899823X26103973_ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0591-6"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X26103973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:33:42Z","timestamp":1771929222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X26103973\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0899823X26103973"],"URL":"https:\/\/doi.org\/10.1017\/ice.2026.10397","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}