{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:51:38Z","timestamp":1792684298525,"version":"4.5.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X26104395_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate factors associated with positive LTBI screening among HCWs and predictors of treatment initiation and completion across hospital sites in Ireland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26104395_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Multicentre retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26104395_as3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Five hospital sites in Ireland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26104395_as4\">\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>N = 755 healthcare workers (HCWs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26104395_as5\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Evaluation of latent tuberculosis infection (LTBI) by interferon gamma release assay in HCWs from high-incidence countries during 2023, identified via occupational health records. IGRA positivity rates, linkage to treatment and treatment outcomes were recorded. Demographic and occupational factors associated with these outcomes were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26104395_as6\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were n = 755 HCWs from high-incidence TB countries identified via occupational health records eligible for LTBI screening. 719 underwent IGRA testing, of whom 93 (13%) were positive. Age &gt; 50 was associated with IGRA positivity (OR 5.71; 95% CI 1.79\u201318.17;\n                      <jats:italic>P<\/jats:italic>\n                      = .003). In addition to these n = 93 HCWs, two additional sites provided treatment outcomes for n = 164 HCWs, and a further n = 58 IGRA-positive HCWs were referred to Site 1. Among these 313 IGRA-positive HCWs, 50% initiated therapy, with substantial variation across sites (27%\u201388%). Multivariable analysis showed study site, but not demographic factors, predicted treatment initiation (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Common reasons for non-initiation included treatment refusal and non-attendance. Treatment completion was high (82%) and was not associated with study site.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26104395_as7\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LTBI prevalence among HCWs in Ireland was lower than international estimates. While treatment initiation was low, completion was high. Treatment initiation varied by site, driven by institutional rather than individual factors. A standardised national programmatic approach is needed for HCWs within the LTBI cascade of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2026.10439","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:28:29Z","timestamp":1776076109000},"page":"618-625","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Latent tuberculosis infection screening and treatment outcomes in healthcare workers in Irish hospitals: a multi-centre cohort study"],"prefix":"10.1017","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2211-9356","authenticated-orcid":false,"given":"Melva","family":"Tan","sequence":"first","affiliation":[{"name":"Mater Misericordiae University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Albaggal","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s University 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P.","family":"Natin","sequence":"additional","affiliation":[{"name":"Mater Misericordiae University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0458-7656","authenticated-orcid":false,"given":"Maria","family":"Lenehan","sequence":"additional","affiliation":[{"name":"Mater Misericordiae University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"McCullagh","sequence":"additional","affiliation":[{"name":"Mater Misericordiae University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Dolan","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-2832","authenticated-orcid":false,"given":"Eleanor","family":"Cronin","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s University 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The end TB strategy, 2015. https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/the-end-tb-strategy. Accessed March 3, 2026."},{"key":"S0899823X26104395_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0595-5"},{"key":"S0899823X26104395_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1550-y"},{"key":"S0899823X26104395_ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104875"},{"key":"S0899823X26104395_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30531-X"},{"key":"S0899823X26104395_ref30","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01245-2015"},{"key":"S0899823X26104395_ref8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00039906"},{"key":"S0899823X26104395_ref12","unstructured":"12. HPSC. National Tuberculosis (TB) guidelines for Ireland 2024\/2025. https:\/\/www.hpsc.ie\/a-z\/vaccinepreventable\/tuberculosistb\/guidance\/. 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Programmatic management of latent tuberculosis infection in the European Union: European Centre for Disease Prevention and Control. 2018."}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X26104395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:12:07Z","timestamp":1779876727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X26104395\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0899823X26104395"],"URL":"https:\/\/doi.org\/10.1017\/ice.2026.10439","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}