{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:50:46Z","timestamp":1791809446127,"version":"4.3.4"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X26105297_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      aureus is a common pathogen that can cause nosocomial infection. Ethyl alcohol has emerged as a potential alternative to mupirocin and povidone-iodine for nasal decolonization; however, data on real-world application are limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26105297_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A quasi-experiment study was performed. Twice daily 62% ethyl alcohol nasal swabs were offered to inpatients at risk for MRSA acquisition. Compliance was monitored and reasons for non-adherence were evaluated. Rates of hospital-onset\n                      <jats:italic>S. aureus<\/jats:italic>\n                      bacteremia were compared pre and postintervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26105297_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 274,999 doses of ethyl alcohol were administered to 12,179 high-risk inpatients with a compliance rate of 82.7%. Reasons for non-compliance centered on product characteristics, patient comorbidities, and perceived lack of benefit from patients and healthcare personnel. There were fewer overall hospital-onset\n                      <jats:italic>S. aureus<\/jats:italic>\n                      bacteremia events (1.97 events\/10,000 patients days predecolonization compared to 1.49 events\/10,000 patient days with decolonization, P = .013). This difference was primarily driven by reduced MRSA bacteremia events (0.61 events\/10,000 patient days predecolonization versus 0.36 with decolonization, P = .009) rather than MSSA bacteremia events (1.31 events\/10,000 patient days predecolonization versus 1.13 events\/10,000 patient days with decolonization, P = .232). On a per-patient basis during the intervention period, there were fewer MRSA bacteremia events in patients receiving decolonization (6.57 events per 10,000 patients) compared to high-risk, but eligible, patients who did not receive decolonization (19.62 episodes per 10,000 patients, P = .044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X26105297_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Twice daily ethyl alcohol nasal treatment may be a viable alternative to existing S. aureus nasal decolonization options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/ice.2026.10529","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:38:58Z","timestamp":1787801938000},"page":"1007-1011","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Impact of ethyl alcohol nasal treatment on hospital-onset\n                    <i>Staphylococcus aureus<\/i>\n                    bacteremia at a tertiary health system"],"prefix":"10.1017","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9582-9050","authenticated-orcid":false,"given":"Donna","family":"Nucci","sequence":"first","affiliation":[{"name":"Yale New Haven Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Sather","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aniskiewicz","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-6716","authenticated-orcid":false,"given":"Scott C.","family":"Roberts","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"S0899823X26105297_ref9","doi-asserted-by":"publisher","DOI":"10.1086\/596045"},{"key":"S0899823X26105297_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/320151"},{"key":"S0899823X26105297_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.266"},{"key":"S0899823X26105297_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.07.032"},{"key":"S0899823X26105297_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2014.04.008"},{"key":"S0899823X26105297_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2022.03.048"},{"key":"S0899823X26105297_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2025.08.006"},{"key":"S0899823X26105297_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2014.12"},{"key":"S0899823X26105297_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab696"},{"key":"S0899823X26105297_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440102"},{"key":"S0899823X26105297_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2023.102"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X26105297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:38:00Z","timestamp":1791808680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X26105297\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0899823X26105297"],"URL":"https:\/\/doi.org\/10.1017\/ice.2026.10529","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}