{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:40:50Z","timestamp":1762875650613},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ir. j. psychol. Med."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec id=\"S0790966714000676_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>In this case report we attempt to emphasize the unfamiliar link between trazodone and relapse of psychotic symptoms.<\/jats:p><\/jats:sec><jats:sec id=\"S0790966714000676_abs2\" sec-type=\"general\"><jats:title>Method<\/jats:title><jats:p>Case report and literature review of relevant papers.<\/jats:p><\/jats:sec><jats:sec id=\"S0790966714000676_abs3\" sec-type=\"general\"><jats:title>Results<\/jats:title><jats:p>We report a case of a 78-year-old woman with an established diagnosis of paranoid schizophrenia who has experienced an exacerbation of positive psychotic symptoms following initiation of 50 mg dailydose of trazodone. We noted that psychotic symptoms abated following discontinuation of trazodone.<\/jats:p><\/jats:sec><jats:sec id=\"S0790966714000676_abs4\" sec-type=\"general\"><jats:title>Conclusion<\/jats:title><jats:p>Trazodone use in patients in remission from schizophrenia may be associated with relapse of psychotic symptoms and caution is required.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ipm.2014.67","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T05:44:11Z","timestamp":1417585451000},"page":"337-339","source":"Crossref","is-referenced-by-count":3,"title":["Trazodone and exacerbation of psychotic symptoms: an unfamiliar link"],"prefix":"10.1017","volume":"32","author":[{"given":"M.","family":"Osman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kilduff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"S0790966714000676_ref4","first-page":"4","article-title":"Mechanism of action of antidepressant medications","volume":"60","author":"Feighner","year":"1999","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0790966714000676_ref20","first-page":"18","article-title":"Evaluating antidepressant therapies: remission as the optimal outcome","volume":"64","author":"Thase","year":"2003","journal-title":"The Journal of Clinical Psychiatry"},{"key":"S0790966714000676_ref53","unstructured":"Electronic Medicines Compendium (2009). Summary of Product Characteristics. http:\/\/www.medicines.org.uk\/emc\/medicine\/26734. 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