{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:31:51Z","timestamp":1761863511404},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ir. j. psychol. Med."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec id=\"S0790966715000488_abs1\" sec-type=\"Background\"><jats:title>Background<\/jats:title><jats:p>We report the case of a 52-year-old male with pre-motor Huntington\u2019s disease (HD) who has undergone detailed clinical and neuropsychological examination. This patient\u2019s negative symptomatology and behavioural change are having a detrimental impact on his social, occupational and interpersonal life, in the absence of motor symptoms.<\/jats:p><\/jats:sec><jats:sec id=\"S0790966715000488_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The patient has undergone repeat neuropsychological testing (T1 aged 50; T2 aged 52) with particular focus on executive function and social cognition on repeat testing.<\/jats:p><\/jats:sec><jats:sec id=\"S0790966715000488_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>This case details a specific manifestation of HD relating to behavioural, psychiatric and social affective deficits.<\/jats:p><\/jats:sec><jats:sec id=\"S0790966715000488_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>This case illustrates how social cognitive changes can occur in HD, months and even years prior to the onset of motor features and how such unrecognized deficits can have a deleterious impact on an individual\u2019s functional ability and lifestyle, before the disease is traditionally considered to have become manifest.<\/jats:p><\/jats:sec>","DOI":"10.1017\/ipm.2015.48","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T05:49:05Z","timestamp":1445838545000},"page":"53-58","source":"Crossref","is-referenced-by-count":2,"title":["Atypical social cognitive processing in premotor Huntington\u2019s disease: a single case study"],"prefix":"10.1017","volume":"34","author":[{"given":"T.","family":"Burke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Healy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Casey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Hardiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"S0790966715000488_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00221-X"},{"key":"S0790966715000488_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704102191"},{"key":"S0790966715000488_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2008.04.018"},{"key":"S0790966715000488_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3109"},{"key":"S0790966715000488_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.07.003"},{"key":"S0790966715000488_ref25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3233\/JHD-120030","article-title":"Longitudinal neuroimaging biomarkers in Huntington\u2019s disease","volume":"2","author":"Rees","year":"2013","journal-title":"Journal of Huntington\u2019s Disease"},{"key":"S0790966715000488_ref19","first-page":"1757","article-title":"Visual impairment and posterior cortical atrophy preceding rapid progressive dementia","volume":"2","author":"M\u00fcller","year":"2013","journal-title":"BMJ Case Reports"},{"key":"S0790966715000488_ref6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"S0790966715000488_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.05.021"},{"key":"S0790966715000488_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/13803390902926184"},{"key":"S0790966715000488_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.06.002"},{"key":"S0790966715000488_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"S0790966715000488_ref8","doi-asserted-by":"publisher","DOI":"10.1080\/02699939208411068"},{"key":"S0790966715000488_ref11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3233\/JHD-130059","article-title":"Cognition in Huntington\u2019s disease in manifest, pre-manifest and converting gene carriers over ten years","volume":"2","author":"Hart","year":"2013","journal-title":"Journal of Huntington\u2019s Disease"},{"key":"S0790966715000488_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.05.019"},{"key":"S0790966715000488_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500360001001"},{"key":"S0790966715000488_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"S0790966715000488_ref9","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.48.4.384"},{"key":"S0790966715000488_ref30","doi-asserted-by":"publisher","DOI":"10.1162\/089892998562942"},{"key":"S0790966715000488_ref10","volume-title":"Frontal Systems Behaviour Scale: Professional Manual","author":"Grace","year":"2001"},{"key":"S0790966715000488_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.32.7.524"},{"key":"S0790966715000488_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm107"},{"key":"S0790966715000488_ref16","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/S0028-3932(03)00079-4","article-title":"Differential deficits in expression recognition in gene-carriers and patients with Huntington\u2019s disease","volume":"41","author":"Midlers","year":"2003","journal-title":"Neuropsychologia"},{"key":"S0790966715000488_ref2","unstructured":"Bowers D , Blonder XM , Heilman KM (1999). The Florida Affect Battery Revised: Introduction to the Florida Affect Battery. neurology.ufl.edu\/files\/2011\/12\/florida-affect-battery-manual.pdf. Last accessed 7 August 2014."},{"key":"S0790966715000488_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60111-1"},{"key":"S0790966715000488_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12195"},{"key":"S0790966715000488_ref24","volume-title":"Repeatable Battery for the Assessment of Neuropsychological Status Manual","author":"Randolph","year":"1998"},{"key":"S0790966715000488_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25997"},{"key":"S0790966715000488_ref23","first-page":"1233","article-title":"Cognitive decline in prodromal Huntington\u2019s disease: implications for clinical trials","volume":"84","author":"Paulsen","year":"2013","journal-title":"Cognitive Neurology"},{"key":"S0790966715000488_ref17","volume-title":"The Personality Assessment Inventory Professional Manual","author":"Morey","year":"1991"},{"key":"S0790966715000488_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.07.012"}],"container-title":["Irish Journal of Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0790966715000488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T08:10:07Z","timestamp":1599725407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0790966715000488\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0790966715000488"],"URL":"https:\/\/doi.org\/10.1017\/ipm.2015.48","relation":{},"ISSN":["0790-9667","2051-6967"],"issn-type":[{"value":"0790-9667","type":"print"},{"value":"2051-6967","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]}}}