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Evidence of the lifetime effects of adverse childhood experiences and inequalities is presented: these are the \u2018causes of the causes\u2019. Seven drivers of physical disorders are illustrated that drive preventable deaths and as doctors, psychiatrists must lead from the front to reverse rising mortality. Evidence supports universal and selective interventions and even the most difficult challenges such as weight gain and opioid misuse are an opportunity for psychiatry to engage with individual patients and their organisations, public health colleagues, health systems and beyond. Interventions complement and do not replace existing clinical practices that reduce self-harm and prevent suicide. Mental health teams already do most of the work in this arena, and the case is made to refocus on physical health with task sharing. The top 10 recommendations within a personalised medicine framework are listed in this paper\u00a0as a starting point.<\/jats:p>","DOI":"10.1017\/ipm.2022.3","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:41:18Z","timestamp":1648734078000},"page":"74-83","source":"Crossref","is-referenced-by-count":8,"title":["Premature mortality of people with severe mental illness: a renewed focus for a new era"],"prefix":"10.1017","volume":"40","author":[{"given":"Peter","family":"Byrne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"S0790966722000039_ref41","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.2742"},{"key":"S0790966722000039_ref2","volume-title":"Communities in Action: Pathways to Health Equity","author":"Baciu","year":"2017"},{"key":"S0790966722000039_ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.585618"},{"key":"S0790966722000039_ref23","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2020-0980"},{"key":"S0790966722000039_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30003-X"},{"key":"S0790966722000039_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1000-9"},{"key":"S0790966722000039_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13004"},{"key":"S0790966722000039_ref36","volume-title":"Preventing Mental Illness: Mental Health Promotion in Primary Care","author":"Jenkins","year":"1998"},{"key":"S0790966722000039_ref5","unstructured":"Baumgartner, JC , Radley, DC (2021). 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