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Individuals with this genetic lactase persistence (LP) variant generally consume more milk and have been shown to have higher levels of serum vitamin D. Vitamin D is the principal regulator of Ca absorption and its synthesis in skin is dependent on UVB exposure. The primary aim of the present study was to compare serum vitamin D concentrations with LP variant and to control for UVB exposure. Data from over 100 000 individuals living in Norway, a country with low UVB exposure, was retrospectively retrieved for comparison of genetic LP variant, serum 25-hydroxyvitamin D (25(OH)D) concentration and the time of year when serum samples were taken. For comparison, a similar analysis was performed with a natural dairy micronutrient, namely vitamin B<jats:sub>12<\/jats:sub>. It was found that individuals with the genetic LP variant had considerably higher levels of serum 25(OH)D (<jats:italic>P<\/jats:italic> &lt; 2 \u00d7 10<jats:sup>\u221216<\/jats:sup>, Cohen's <jats:italic>d<\/jats:italic> = 0\u00b773) but lower levels of vitamin B<jats:sub>12<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 2 \u00d7 10<jats:sup>\u221216<\/jats:sup>, Cohen's <jats:italic>d<\/jats:italic> = 0\u00b711), compared with genetic lactase non-persistent individuals, even when controlled for seasonality, age and sex. The difference in serum 25(OH)D levels did not diminish in summer months, showing the role of vitamin D in LP variant selection in areas of low UVB irradiation. LP variant selection advantage through acquiring another dairy micronutrient, vitamin B<jats:sub>12<\/jats:sub>, was not observed.<\/jats:p>","DOI":"10.1017\/jns.2019.41","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T06:36:21Z","timestamp":1578897381000},"source":"Crossref","is-referenced-by-count":3,"title":["The Eurasian lactase persistence variant <i>LCT<\/i>-13910 C\/T is associated with vitamin D levels in individuals living at high latitude, more so than exposure to 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