{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:17:43Z","timestamp":1763018263857},"reference-count":16,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"unspecified","delay-in-days":315,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2020]]},"abstract":"Abstract<\/jats:title>\n\t Neonatal mortality rates in Indonesia are still at an alarming rate, with preterm birth as one of the causes. Nutritional deficiencies such as low level of vitamin D is suspected to be the risk factors of preterm birth but still a little knowledge about it. Vitamin D metabolism includes 25-hydroxyvitamin D3<\/jats:sub> (25(OH)D3<\/jats:sub>) and 1,25-dihydroxyvitamin D3<\/jats:sub> (1,25(OH)2<\/jats:sub>D3<\/jats:sub>), as the inactive and active form, with the help of 1\u03b1-hydroxylase (CYP27B1) enzyme. Our study aims to determine the differences of 25(OH)D3<\/jats:sub>, 1,25(OH)2<\/jats:sub>D3<\/jats:sub> and CYP27B1 enzyme in term and preterm birth. A cross-sectional study was performed in Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, in January\u2013June 2017. The blood sample was taken soon after delivery, to examine maternal 25(OH)D3<\/jats:sub> and 1,25(OH)2<\/jats:sub>D3<\/jats:sub> in serum and tissue placenta, as well as placental CYP27B1 enzyme. Statistical analysis using SPPS version 20 was used to find significances. There were a total of sixty subjects in this study, with term-preterm birth group ratio 1:1. We found that placental 25(OH)D3<\/jats:sub> was significantly low (P<\/jats:italic> = 0\u22c5001), and CYP27B1\/25(OH)D3<\/jats:sub> ratio was high in preterm birth. Also, there were significant negative correlations found in CYP27B1 level and both placental 25(OH)D3<\/jats:sub> (r<\/jats:italic> 0\u22c5481, P<\/jats:italic> < 0\u22c5001) and 1,25(OH)2<\/jats:sub>D3<\/jats:sub> (r<\/jats:italic> \u22120\u22c5365, P<\/jats:italic> = 0\u22c5004) levels. Our study concludes that preterm birth showed lower placental 25(OH)D3<\/jats:sub> status, and higher CYP27B1\/25(OH)D3<\/jats:sub> ratio compared to term pregnancy.<\/jats:p>","DOI":"10.1017\/jns.2020.42","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T13:14:50Z","timestamp":1605100490000},"source":"Crossref","is-referenced-by-count":5,"title":["Lower placental 25-hydroxyvitamin D3<\/sub> (25(OH)D3<\/sub>) and higher placental CYP27B1 and 25(OH)D3<\/sub> ratio in preterm birth"],"prefix":"10.1017","volume":"9","author":[{"given":"Rima","family":"Irwinda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biancha","family":"Andardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"S2048679020000427_ref14","unstructured":"14. Tamblyn, JA (2017) Vitamin D in pregnancy: understanding immune effects in the decidua. PhD Thesis, University of Birmingham."},{"key":"S2048679020000427_ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5062365"},{"key":"S2048679020000427_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.08.015"},{"key":"S2048679020000427_ref11","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.765849"},{"key":"S2048679020000427_ref3","first-page":"599","volume-title":"Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice","author":"Buhimschi","year":"2014"},{"key":"S2048679020000427_ref16","first-page":"1","article-title":"Regulation of CYP27B1 and CYP24A1 gene expression by recombinant pro-inflammatory cytokines in cultured human trophoblasts","volume":"1","author":"Noyola-Martinez","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"S2048679020000427_ref7","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0642"},{"key":"S2048679020000427_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.052"},{"key":"S2048679020000427_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12210"},{"key":"S2048679020000427_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.01.002"},{"key":"S2048679020000427_ref4","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.081777"},{"key":"S2048679020000427_ref1","volume-title":"Maternal and Newborn Health Disparities \u2013 Indonesia","year":"2018"},{"key":"S2048679020000427_ref2","unstructured":"2. WHO (2018) Preterm Birth [internet]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/preterm-birth (accessed June 2020)."},{"key":"S2048679020000427_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112459225"},{"key":"S2048679020000427_ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050301"},{"key":"S2048679020000427_ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-072610-145141"}],"container-title":["Journal of Nutritional Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2048679020000427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T13:15:02Z","timestamp":1605100502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2048679020000427\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":16,"alternative-id":["S2048679020000427"],"URL":"https:\/\/doi.org\/10.1017\/jns.2020.42","relation":{},"ISSN":["2048-6790"],"issn-type":[{"value":"2048-6790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e50"}}