{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:51:16Z","timestamp":1793206276419,"version":"4.5.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"unspecified","delay-in-days":346,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>The recommended daily dose of vitamin D is 2000 IU was found to be insufficient in many patients. The objective of the present study is to find whether the daily dose of vitamin D should be based on BMI. Two hundred and thirty patients with an established vitamin D deficiency (serum level of 25 Hydroxy vitamin D3 (25OHD3) of \u226420 ng\/ml) and patients with BMI \u226530 kg\/m<jats:sup>2<\/jats:sup> were included in the study. Demographic data, comorbidities and BMI were recorded. Pre-treatment and post-treatment serum 25OHD3, calcium, phosphorus and parathyroid hormone (PTH) were tested at 0-, 3- and 6-month periods. Patients were treated with a standard dose of 50 000 IU of vitamin D weekly and 600\/1200 mg of calcium a day. Once their level of 25OHD3 reached \u226530 ng\/ml, patients were randomised into two groups. Group A received a standard recommended maintenance dose of 2000 IU daily and Group B patients received 125 IU\/kg\/m<jats:sup>2<\/jats:sup> of vitamin D3. The data were entered in the database and analysed. The mean age of Group A was 50\u22c574 \u00b1 7\u22c564 years compared to 52\u22c532 \u00b1 7\u22c521 years in Group B. In both groups, pre-treatment vitamin D level was \u226415 ng\/ml and increased to 34\u22c56 \u00b1 2\u22c56 and 33\u22c57 \u00b1 2\u22c54 ng\/ml at the end of 3 months treatment with a dose 50 000 IU of vitamin D3 and calcium 600\/1200 mg once a day for group A and group B, respectively. At 6 months, patients in Group A 25OHD3 level was 22\u22c58 \u00b1 3\u22c580 and in Group B was 34\u22c50 \u00b1 1\u22c585 ng\/ml (<jats:italic>P<\/jats:italic> &lt; 0\u22c5001). This preliminary study suggests that obese patients need higher dosage of vitamin D than the recommended dose. It is prudent that the dosage should be based on the BMI to maintain normal levels for a healthy musculoskeletal system.<\/jats:p>","DOI":"10.1017\/jns.2021.100","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T09:52:54Z","timestamp":1639389174000},"source":"Crossref","is-referenced-by-count":15,"title":["Time out: should vitamin D dosing be based on patient's body mass index (BMI): a prospective controlled study"],"prefix":"10.1017","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-0830","authenticated-orcid":false,"given":"Mir","family":"Sadat-Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid W.","family":"AlTabash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa A.","family":"Al-Turki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman A.","family":"AlMousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan N.","family":"AlSayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"S2048679021001002_ref23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1909301"},{"key":"S2048679021001002_ref9","first-page":"296","article-title":"Vitamin D: a Millenium perspective","volume":"88","author":"Holick","year":"2003","journal-title":"J Cell Bio-chem"},{"key":"S2048679021001002_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14636-3"},{"key":"S2048679021001002_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000371"},{"key":"S2048679021001002_ref21","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1765"},{"key":"S2048679021001002_ref12","doi-asserted-by":"publisher","DOI":"10.4103\/GFSC.GFSC_4_20"},{"key":"S2048679021001002_ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003605"},{"key":"S2048679021001002_ref10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29449"},{"key":"S2048679021001002_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.03.010"},{"key":"S2048679021001002_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1004-2"},{"key":"S2048679021001002_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9693-3"},{"key":"S2048679021001002_ref24","volume-title":"National Health Survey: First Results, 2014\u201315. 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