{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:31:48Z","timestamp":1785879108571,"version":"3.56.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"unspecified","delay-in-days":51,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Since the discovery of vitamin D, it has been accepted that its physiological supply is either from food or by endogenous synthesis in skin exposed to solar UV light. Yet vitamin D is a component of very few foods and its supply as a natural nutrient is unable to maintain good vitamin D status for human populations. One aspect of vitamin D physiology that has been ignored is that the mechanisms for its transport and processing from these two sources are quite different. Excess intake of vitamin D causes hypercalcaemic toxicity. However, experiments with different animal species have shown that long-term supply of oral vitamin D in apparently non-toxic amounts causes atherosclerosis in large arteries. A mechanism for this toxicity is proposed. Alternative strategies for addressing widespread vitamin D deficiency by food fortification should be considered in light of the angiotoxicity caused by oral vitamin D in animal experiments.<\/jats:p>","DOI":"10.1017\/jns.2022.11","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:31:57Z","timestamp":1645453917000},"source":"Crossref","is-referenced-by-count":17,"title":["Physiological significance of vitamin D produced in skin compared with oral vitamin D"],"prefix":"10.1017","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-0750","authenticated-orcid":false,"given":"David R.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"S2048679022000118_ref16","doi-asserted-by":"publisher","DOI":"10.1290\/1071-2690(2000)036<0201:AHSEMT>2.0.CO;2"},{"key":"S2048679022000118_ref25","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-1-498"},{"key":"S2048679022000118_ref8","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.031427"},{"key":"S2048679022000118_ref24","first-page":"E326","article-title":"Plasma clearance, transfer, and distribution of vitamin D3 from intestinal lymph","volume":"245","author":"Dueland","year":"1983","journal-title":"Am J Physiol"},{"key":"S2048679022000118_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129836"},{"key":"S2048679022000118_ref10","volume-title":"Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium","author":"Ross","year":"2011"},{"key":"S2048679022000118_ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203253061206"},{"key":"S2048679022000118_ref26","first-page":"1","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr Physiol"},{"key":"S2048679022000118_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux034"},{"key":"S2048679022000118_ref9","article-title":"Global differences in vitamin D status and dietary intake: a review of the data","volume":"1","author":"Cashman","year":"2021","journal-title":"Endocr Connect"},{"key":"S2048679022000118_ref17","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.07s221"},{"key":"S2048679022000118_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400042686"},{"key":"S2048679022000118_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01935064"},{"key":"S2048679022000118_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-013-9574-0"},{"key":"S2048679022000118_ref18","doi-asserted-by":"publisher","DOI":"10.1126\/science.6251551"},{"key":"S2048679022000118_ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00317"},{"key":"S2048679022000118_ref13","doi-asserted-by":"publisher","DOI":"10.3390\/nu10040457"},{"key":"S2048679022000118_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0309-1651(77)90015-7"},{"key":"S2048679022000118_ref4","doi-asserted-by":"publisher","DOI":"10.3390\/nu2050482"},{"key":"S2048679022000118_ref3","first-page":"xi","article-title":"The part played by an \u2018accessory factor\u2019 in the production of experimental rickets","volume":"52","author":"Mellanby","year":"1918","journal-title":"J Physiol"},{"key":"S2048679022000118_ref32","first-page":"229","article-title":"Role of mild excesses of vitamin D3 in arteriosclerosis. A study in squirrel monkeys","volume":"4","author":"Peng","year":"1978","journal-title":"Paroi Arterielle"},{"key":"S2048679022000118_ref11","doi-asserted-by":"publisher","DOI":"10.3109\/00365518009095571"},{"key":"S2048679022000118_ref27","doi-asserted-by":"publisher","DOI":"10.1038\/2201031a0"},{"key":"S2048679022000118_ref20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116492"},{"key":"S2048679022000118_ref21","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2015"},{"key":"S2048679022000118_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10453"},{"key":"S2048679022000118_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu8090533"},{"key":"S2048679022000118_ref12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112134"},{"key":"S2048679022000118_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.10.012"},{"key":"S2048679022000118_ref33","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/140267"},{"key":"S2048679022000118_ref19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915442116"},{"key":"S2048679022000118_ref14","doi-asserted-by":"publisher","DOI":"10.1039\/C6PP00034G"},{"key":"S2048679022000118_ref15","doi-asserted-by":"publisher","DOI":"10.2114\/jpa2.27.71"}],"container-title":["Journal of Nutritional Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2048679022000118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:32:10Z","timestamp":1645453930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2048679022000118\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":33,"alternative-id":["S2048679022000118"],"URL":"https:\/\/doi.org\/10.1017\/jns.2022.11","relation":{},"ISSN":["2048-6790"],"issn-type":[{"value":"2048-6790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e13"}}