{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:15:28Z","timestamp":1789827328143,"version":"4.0.1"},"reference-count":93,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"unspecified","delay-in-days":117,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008359","name":"Maag Lever Darm Stichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Constipation can greatly impact the quality of life (QoL), which can be relieved by dietary fibres; however, preserving a higher fibre intake remains a challenge. We investigated the effects of a personalised dietary advice (PDA) on fibre intake and mild constipation complaints. A total number of twenty-five adults with mild constipation complaints were included in a 4-week observation period followed by a 4-week personalised intervention. The PDA provided high-fibre alternatives via a web tool. In weeks 1, 4 and 8, dietary intake, constipation complaints and QoL were assessed. Furthermore, participants collected a faecal sample at weeks 1, 4 and 8 to determine microbiota diversity and composition, and short-chain fatty acids (SCFA). Participants completed questions daily for 8 weeks regarding abdominal complaints, stool frequency and stool consistency. Fibre intake in week 8 was significantly higher compared to week 1 (<jats:italic>\u0394<\/jats:italic>= 5\u00b77 \u00b1 6\u00b77 g,<jats:italic>P<\/jats:italic>&lt; 0\u00b7001) and week 4 (<jats:italic>\u0394<\/jats:italic>= 5\u00b72 \u00b1 6\u00b74 g,<jats:italic>P<\/jats:italic>&lt; 0\u00b7001). Constipation severity and QoL significantly improved at week 8 compared to the observation period (<jats:italic>P<\/jats:italic>&lt; 0\u00b7001). A higher fibre intake significantly reduced constipation severity (<jats:italic>\u03b2<\/jats:italic>= \u22120\u00b7031 (\u22120\u00b705; \u22120\u00b701),<jats:italic>P<\/jats:italic>= 0\u00b7001) and the QoL (<jats:italic>\u03b2<\/jats:italic>= \u22120\u00b7022 (\u22120\u00b704; \u22120\u00b701),<jats:italic>P<\/jats:italic>= 0\u00b7009). Stool consistency (<jats:italic>P<\/jats:italic>= 0\u00b7040) and abdominal pain (<jats:italic>P<\/jats:italic>= 0\u00b7030) improved significantly during the intervention period (<jats:italic>P<\/jats:italic>= 0\u00b7040), but stool frequency did not. Average microbial alpha diversity and composition and SCFA concentrations did not change over time, but indicated individual-specific dynamics. Several SCFAs were associated with constipation complaints. To conclude, a PDA effectively increased fibre intake and subsequently reduced constipation complaints, indicating that guided dietary adjustments are important and feasible in the treatment of mild constipation complaints.<\/jats:p>","DOI":"10.1017\/jns.2022.27","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T12:31:05Z","timestamp":1653395465000},"source":"Crossref","is-referenced-by-count":8,"title":["A high-fibre personalised dietary advice given via a web tool reduces constipation complaints in adults"],"prefix":"10.1017","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-6669","authenticated-orcid":false,"given":"Iris","family":"Rijnaarts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-1678","authenticated-orcid":false,"given":"Nicole M.","family":"de Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-3864","authenticated-orcid":false,"given":"Taojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-0727","authenticated-orcid":false,"given":"Erwin G.","family":"Zoetendal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-5880","authenticated-orcid":false,"given":"Jan","family":"Top","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Timmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7263-0920","authenticated-orcid":false,"given":"Koen","family":"Hogenelst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5633-7425","authenticated-orcid":false,"given":"Emily P.","family":"Bouwman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-8540","authenticated-orcid":false,"given":"Ben","family":"Witteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-8836","authenticated-orcid":false,"given":"Nicole","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"S2048679022000271_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2010.10.012"},{"key":"S2048679022000271_ref48","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510012208"},{"key":"S2048679022000271_ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"S2048679022000271_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03376.x"},{"key":"S2048679022000271_ref16","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2016.1212819"},{"key":"S2048679022000271_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010091"},{"key":"S2048679022000271_ref25","first-page":"727","article-title":"Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation","volume":"45","author":"Anti","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"S2048679022000271_ref38","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-75"},{"key":"S2048679022000271_ref76","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.076901"},{"key":"S2048679022000271_ref80","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2008.10719740"},{"key":"S2048679022000271_ref62","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1209"},{"key":"S2048679022000271_ref90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03884.x"},{"key":"S2048679022000271_ref91","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39524.439618.25"},{"key":"S2048679022000271_ref79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085133"},{"key":"S2048679022000271_ref14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7378"},{"key":"S2048679022000271_ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2013.05.016"},{"key":"S2048679022000271_ref82","first-page":"1","article-title":"Fat, fibre and cancer risk in African Americans and rural Africans","volume":"6","author":"O'Keefe","year":"2015","journal-title":"Nat Commun"},{"key":"S2048679022000271_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00220-8"},{"key":"S2048679022000271_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12789"},{"key":"S2048679022000271_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01642.x"},{"key":"S2048679022000271_ref49","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.3.022806.091415"},{"key":"S2048679022000271_ref58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00283.2019"},{"key":"S2048679022000271_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.05.016"},{"key":"S2048679022000271_ref71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04602.x"},{"key":"S2048679022000271_ref83","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.9.819"},{"key":"S2048679022000271_ref87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01324.x"},{"key":"S2048679022000271_ref86","doi-asserted-by":"publisher","DOI":"10.2174\/1389200211314090006"},{"key":"S2048679022000271_ref46","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/003655299750025327","article-title":"Psychometric validation of a constipation symptom assessment questionnaire","volume":"34","author":"Frank","year":"1999","journal-title":"Scand J Gastroenterol"},{"key":"S2048679022000271_ref89","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12217"},{"key":"S2048679022000271_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000308660.48204.7f"},{"key":"S2048679022000271_ref35","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980020002980"},{"key":"S2048679022000271_ref53","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2017.45"},{"key":"S2048679022000271_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000224"},{"key":"S2048679022000271_ref56","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"key":"S2048679022000271_ref34","first-page":"578","article-title":"Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial","volume":"46","author":"Celis-Morales","year":"2016","journal-title":"Int J Epidemiol"},{"key":"S2048679022000271_ref8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1365-2036.2008.03806.x","article-title":"A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation","volume":"28","author":"Wald","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"S2048679022000271_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2019.06.006"},{"key":"S2048679022000271_ref66","doi-asserted-by":"publisher","DOI":"10.1093\/her\/cyt076"},{"key":"S2048679022000271_ref69","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8228-8235.2005"},{"key":"S2048679022000271_ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-510"},{"key":"S2048679022000271_ref45","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12941"},{"key":"S2048679022000271_ref72","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13662"},{"key":"S2048679022000271_ref73","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.200"},{"key":"S2048679022000271_ref74","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13149"},{"key":"S2048679022000271_ref15","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2010.527323"},{"key":"S2048679022000271_ref64","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-016-0414-6"},{"key":"S2048679022000271_ref50","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.170"},{"key":"S2048679022000271_ref75","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1002212"},{"key":"S2048679022000271_ref67","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14349"},{"key":"S2048679022000271_ref44","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614527283"},{"key":"S2048679022000271_ref68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"S2048679022000271_ref29","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-374"},{"key":"S2048679022000271_ref42","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20392"},{"key":"S2048679022000271_ref27","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8229.134766"},{"key":"S2048679022000271_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2010.02.007"},{"key":"S2048679022000271_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2012.01.021"},{"key":"S2048679022000271_ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00336.x"},{"key":"S2048679022000271_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01709.x"},{"key":"S2048679022000271_ref32","unstructured":"32. Van Rossum, C , Buurma-Rethans, E , Dinnissen, C , (2016) The diet of the Dutch: Results of the Dutch National Food Consumption Survey 2012\u20132016. RIVM letter report 2016-0082"},{"key":"S2048679022000271_ref84","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1031"},{"key":"S2048679022000271_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.1.232"},{"key":"S2048679022000271_ref70","unstructured":"70. R Core Team (2013) R: A Language and Environment for Statistical Computing. Vienna, Austria. https:\/\/www.R-project.org."},{"key":"S2048679022000271_ref22","doi-asserted-by":"publisher","DOI":"10.1080\/10408397509527201"},{"key":"S2048679022000271_ref40","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980019001435"},{"key":"S2048679022000271_ref63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110614"},{"key":"S2048679022000271_ref88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-017-0383-2","article-title":"Aerobic proteobacterial methylotrophs in movile cave: Genomic and metagenomic analyses","volume":"6","author":"Hoyles","year":"2018","journal-title":"Microbiome"},{"key":"S2048679022000271_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.12.021"},{"key":"S2048679022000271_ref85","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13314"},{"key":"S2048679022000271_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13248"},{"key":"S2048679022000271_ref77","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602435"},{"key":"S2048679022000271_ref43","first-page":"920","article-title":"Bristol stool chart","volume":"32","author":"Heaton","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"S2048679022000271_ref10","first-page":"S649","article-title":"Prevalence of Rome IV functional gastrointestinal disorders in children and adolescents in the United States","volume":"152","author":"Zwiener","year":"2017","journal-title":"Gastroenterology"},{"key":"S2048679022000271_ref92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00650.x"},{"key":"S2048679022000271_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.012"},{"key":"S2048679022000271_ref30","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v59.28646"},{"key":"S2048679022000271_ref93","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020131126397"},{"key":"S2048679022000271_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"S2048679022000271_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-3-12"},{"key":"S2048679022000271_ref52","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6722.439"},{"key":"S2048679022000271_ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0886-2"},{"key":"S2048679022000271_ref60","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9227.1"},{"key":"S2048679022000271_ref57","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092193"},{"key":"S2048679022000271_ref39","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511000067"},{"key":"S2048679022000271_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07591.x"},{"key":"S2048679022000271_ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01631.x"},{"key":"S2048679022000271_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/S0148-2963(98)00057-5"},{"key":"S2048679022000271_ref54","unstructured":"54. RIVM. NEVO-online database. Bilthoven2019\/6.0."},{"key":"S2048679022000271_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614528175"},{"key":"S2048679022000271_ref51","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3647-3"},{"key":"S2048679022000271_ref31","unstructured":"31. Health Council of the Netherlands. (2006) Guideline for dietary fiber intake. The Hague: Health Council of the Netherlands. Publication no. 2006\/03."},{"key":"S2048679022000271_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07386.x"},{"key":"S2048679022000271_ref61","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"S2048679022000271_ref78","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27394"}],"container-title":["Journal of Nutritional Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2048679022000271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:12:53Z","timestamp":1700626373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2048679022000271\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":93,"alternative-id":["S2048679022000271"],"URL":"https:\/\/doi.org\/10.1017\/jns.2022.27","relation":{},"ISSN":["2048-6790"],"issn-type":[{"value":"2048-6790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e31"}}