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In eastern Ethiopia, a parallel randomised controlled trial design was employed among women planning to get pregnant. The interventional arm (<jats:italic>n<\/jats:italic> 122) received a preconception picture-based nutrition education and counselling along with an IFAS and the control arm (<jats:italic>n<\/jats:italic> 122) received only a preconception IFAS. The effects of the intervention between-group differences were assessed using a <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> and independent sample <jats:italic>t<\/jats:italic>-test. Bivariate and multivariable linear regression model was fitted to detect independent variables affecting the outcome. The outcome measures regarding the knowledge and adherence to the IFAS intake during the three months of the intervention period were deteremined. It was observed that large proportion of women in the intervention group (42\u22c56 %) had an adherence to IFAS compared to the control group (3\u22c53 %); (<jats:italic>P<\/jats:italic> &lt; 0\u22c50001). Based on bivariate and multivariable linear regression analyses, among NTDs affecting pregnancy, the history of spontaneous abortion and knowledge were independently associated with adherence to the IFAS (<jats:italic>P<\/jats:italic> &lt; 0\u22c505). Preconception nutrition education with regular follow-ups could be effective in improving knowledge and adherence to the IFAS intake. This intervention is very short, simple, cost-effective and has the potential for adaptation development to a large-scale implementation in the existing healthcare system in Ethiopia to prevent NTDs and adverse birth outcomes among women who plan to get pregnant. This clinical trial was registered on 6 April 2021 under the ClinicalTrials.gov with an identifier number PACTR202104543567379.<\/jats:p>","DOI":"10.1017\/jns.2022.51","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T09:39:13Z","timestamp":1657705153000},"source":"Crossref","is-referenced-by-count":22,"title":["Effect of Picture-based health education and counselling on knowledge and adherence to preconception Iron-folic acid supplementation among women planning to be pregnant in Eastern Ethiopia: a randomized controlled trial"],"prefix":"10.1017","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-8703","authenticated-orcid":false,"given":"Anteneh","family":"Berhane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tefera","family":"Belachew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"S2048679022000519_ref46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227090"},{"key":"S2048679022000519_ref48","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2004665"},{"key":"S2048679022000519_ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/295083"},{"key":"S2048679022000519_ref42","unstructured":"42. 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