{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:47Z","timestamp":1787242007476,"version":"build-2736575974"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"unspecified","delay-in-days":333,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inflammation is an underlying problem for many disease states and has been implicated in iron deficiency (ID). This study aimed to determine whether iron status is improved by epigallocatechin-3-gallate (EGCG) through reducing inflammation. Thirty-two male Sprague\u2013Dawley rats were fed an iron-deficient diet for 2 weeks and then randomly divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    8 each): positive controls, negative controls, lipopolysaccharide (LPS, 0\u22c55 mg\/kg body weight), and LPS + EGCG (LPS plus 600 mg EGCG\/kg diet) for 3 additional weeks. The study involved testing two control groups, both treated with saline. One group (positive control) was fed a regular diet containing standard iron, while the negative control was fed an iron-deficient diet. Additionally, two treatment groups were tested. The first group was given LPS, while the second group was administered LPS and fed an EGCG diet. Iron status, hepcidin, C-reactive protein (CRP), serum amyloid A (SAA), and interleukin-6 (IL-6) were measured. There were no differences in treatment groups compared with control in CRP, hepcidin, and liver iron concentrations. Serum iron concentrations were significantly lower in the LPS (\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u22c502) and the LPS + EGCG (\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u22c501) than in the positive control group. Compared to the positive control group, spleen iron concentrations were significantly lower in the negative control (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u22c5001) but not with both LPS groups. SAA concentrations were significantly lower in the LPS + EGCG group compared to LPS alone group. EGCG reduced SAA concentrations but did not affect hepcidin or improve serum iron concentration or other iron markers.\n                  <\/jats:p>","DOI":"10.1017\/jns.2023.107","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T03:24:03Z","timestamp":1701314643000},"source":"Crossref","is-referenced-by-count":3,"title":["Effects of green tea polyphenols on inflammation and iron status"],"prefix":"10.1017","volume":"12","author":[{"given":"Mary Carolyn","family":"Jorgenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2374-4462","authenticated-orcid":false,"given":"Sixtus","family":"Aguree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Schalinske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju 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