{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:41:25Z","timestamp":1792075285511,"version":"4.4.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"unspecified","delay-in-days":190,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000308","name":"Carnegie Corporation of New York","doi-asserted-by":"publisher","award":["Grant No: RU\/2020\/GTADRG\/016"],"award-info":[{"award-number":["Grant No: RU\/2020\/GTADRG\/016"]}],"id":[{"id":"10.13039\/100000308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Papaya (<jats:italic>Carica papaya<\/jats:italic>L.) is a highly nutritious and less-caloric fruit, commonly consumed for its minerals and vitamins and hence may help in controlling obesity and abdominal discomforts. The present study investigated the hypolipidaemic effects of papaya juice extract on male Albino Wistar rats (7 weeks old; 185 \u00b1 17 g) fed on a high fat and fructose diet (HFFD) for 6 weeks. The rats were divided into groups I\u2013IV of five rats each and fed on either a HFFD (i.e. the Control), HFFD + 200 mg papaya, HFFD + 350 mg papaya or a HFFD + 500 mg papaya. On day 34, after an overnight fast, blood samples were obtained by cardiac puncture under 99\u22c58\u00a0% Chloroform anaesthesia for the determination of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density cholesterol (HDL-c). The atherogenic (AI) and coronary risk (CRI) indices were also calculated. Statistical analysis was performed using ANOVA where means were separated using Tukey's HSD test. Resulted showed that all rats given papaya juice had an increasing, non-significant HDL-c and reduced LDL-c levels while rats fed on HFFD had the highest TC (53\u22c52 mg\/dl) and TG (37\u22c56 mg\/dl) levels. Papaya juice statistically reduced the AI and CRI of the rats. In conclusion, consumption of HFFD + 500 mg was the most effective in the reduction of rats\u2019 blood lipids and fats, due to its anti-obesity and hypolipidaemic properties, thus can be used in the management of dyspilidaemic disorders.<\/jats:p>","DOI":"10.1017\/jns.2023.61","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T08:57:31Z","timestamp":1688979451000},"source":"Crossref","is-referenced-by-count":9,"title":["Hypolipidaemic effects of papaya (<i>Carica papaya<\/i>L.) juice on rats fed on a high fat and fructose diet"],"prefix":"10.1017","volume":"12","author":[{"given":"Christinah","family":"Matsuane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice N.","family":"Kiage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Karanja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes M.","family":"Kavoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredah K.","family":"Rimberia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"S2048679023000617_ref27","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2019.416"},{"key":"S2048679023000617_ref21","volume-title":"Official Methods of Analysis of AOAC International","author":"Cunniff","year":"1999"},{"key":"S2048679023000617_ref37","first-page":"85","article-title":"Hypoglycaemic and coronary risk index lowering effects of Bauhinia thoningii in alloxan induced diabetic rats","volume":"11","author":"Ojezele","year":"2011","journal-title":"African Health Sci"},{"key":"S2048679023000617_ref35","doi-asserted-by":"publisher","DOI":"10.1089\/met.2013.0128"},{"key":"S2048679023000617_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.08.005"},{"key":"S2048679023000617_ref16","first-page":"25","article-title":"Oral gavage in rats: animal welfare evaluation","volume":"51","author":"Turner","year":"2012","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"S2048679023000617_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1129"},{"key":"S2048679023000617_ref19","first-page":"207","article-title":"High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham study","volume":"8","author":"Abbott","year":"1988","journal-title":"Arteriosclerosis (Dallas, Tex.)"},{"key":"S2048679023000617_ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.741754"},{"key":"S2048679023000617_ref11","first-page":"1","article-title":"Anti-obesity effect of Carica papaya in high-fat diet fed rats","volume":"13","author":"Od-Ek","year":"2020","journal-title":"Biomed Rep"},{"key":"S2048679023000617_ref15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.21315\/mjms2017.24.5.11","article-title":"Sample size calculation in animal studies using resource equation approach","volume":"24","author":"Arifin","year":"2017","journal-title":"Malays J Med Sci"},{"key":"S2048679023000617_ref17","first-page":"109","article-title":"Hypoglycemic, hypolipidemic and body weight effects of unripe pulp of Carica papaya using diabetic albino rat model","volume":"2","author":"Ezekwe","year":"2014","journal-title":"J Pharmacogn Phytochem"},{"key":"S2048679023000617_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"S2048679023000617_ref1","article-title":"Hemolytic activity of Indian medicinal plants towards human erythrocytes: an in vitro study","volume":"40","author":"Kumar","year":"2011","journal-title":"Elixir Appl Bot"},{"key":"S2048679023000617_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2004.07.013"},{"key":"S2048679023000617_ref29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189885"},{"key":"S2048679023000617_ref5","first-page":"565","article-title":"Biochemical properties in peel, pulp and seeds of Carica papaya","volume":"14","author":"Parni","year":"2014","journal-title":"Plant Arch"},{"key":"S2048679023000617_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.05.074"},{"key":"S2048679023000617_ref34","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160909153707"},{"key":"S2048679023000617_ref8","first-page":"137","article-title":"Nutritional analysis of two local varieties of papaya (Carica papaya L.) at different maturation stages","volume":"9","author":"Bari","year":"2006","journal-title":"Pak J Biol Sci"},{"key":"S2048679023000617_ref9","doi-asserted-by":"publisher","DOI":"10.1590\/S0101-20612012005000099"},{"key":"S2048679023000617_ref20","first-page":"893","article-title":"Induction of hypercholesterolemia by supplementing soy protein with acetate generating amino acids","volume":"40","author":"Alladi","year":"1989","journal-title":"Nutr Rep Int"},{"key":"S2048679023000617_ref4","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091304"},{"key":"S2048679023000617_ref12","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.14-0086"},{"key":"S2048679023000617_ref31","doi-asserted-by":"publisher","DOI":"10.1080\/09291016.2018.1558734"},{"key":"S2048679023000617_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-015-0057-7"},{"key":"S2048679023000617_ref3","article-title":"Plants\u2019 metabolites as potential antiobesity agents","author":"Gooda Sahib","year":"2012","journal-title":"Sci World"},{"key":"S2048679023000617_ref39","doi-asserted-by":"publisher","DOI":"10.3923\/ijbc.2012.61.68"},{"key":"S2048679023000617_ref30","doi-asserted-by":"publisher","DOI":"10.23888\/PAVLOVJ201927110-19"},{"key":"S2048679023000617_ref33","doi-asserted-by":"publisher","DOI":"10.3390\/biom9090430"},{"key":"S2048679023000617_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(14)60617-4"},{"key":"S2048679023000617_ref25","doi-asserted-by":"publisher","DOI":"10.1021\/jf020444+"},{"key":"S2048679023000617_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-014-1538-9"},{"key":"S2048679023000617_ref26","doi-asserted-by":"publisher","DOI":"10.17113\/ftb.53.02.15.3833"},{"key":"S2048679023000617_ref13","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101502"},{"key":"S2048679023000617_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4659"},{"key":"S2048679023000617_ref10","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071608"},{"key":"S2048679023000617_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2010.12.035"},{"key":"S2048679023000617_ref7","first-page":"7","article-title":"Traditional and medicinal uses of Carica papaya","volume":"1","author":"Aravind","year":"2013","journal-title":"J Med Plants Stud"}],"container-title":["Journal of Nutritional Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2048679023000617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T22:11:53Z","timestamp":1729721513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2048679023000617\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":39,"alternative-id":["S2048679023000617"],"URL":"https:\/\/doi.org\/10.1017\/jns.2023.61","relation":{},"ISSN":["2048-6790"],"issn-type":[{"value":"2048-6790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e76"}}