{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:33:39Z","timestamp":1782218019999,"version":"3.54.5"},"reference-count":55,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"unspecified","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Folate and vitamin B<jats:sub>12<\/jats:sub> (cobalamin) are essential for growth and development. This cross-sectional study aims to describe folate and vitamin B<jats:sub>12<\/jats:sub> status according to infant age and breastfeeding practices in Norwegian infants. Infants aged 0\u201312 months (<jats:italic>n<\/jats:italic> = 125) were recruited through public health clinics. We registered breastfeeding status and measured serum concentrations of folate, cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA). The associations between infant age, breastfeeding, and biomarker concentrations were estimated in regression models. The mean (SD) age was 24 (16) weeks, and 42% were exclusively breastfed, 38% were partially breastfed, and 21% were weaned. Overall, median (IQR) folate, cobalamin, tHcy, and MMA concentrations were 47 (35\u201366) nmol\/L, 250 (178\u2013368) pmol\/L, 6.99 (5.69\u20139.27) \u00b5mol\/L, and 0.35 (0.24\u20130.83) \u00b5mol\/L, respectively. None of the infants were folate deficient, 15% were vitamin B<jats:sub>12<\/jats:sub> deficient (&lt; 148 pmol\/L), and 23% had low vitamin B<jats:sub>12<\/jats:sub> status (148\u2013221 pmol\/L). Elevated tHcy (&gt; 6.5 \u03bcmol\/L) and MMA (&gt; 0.26 \u03bcmol\/L) were found in 62% and 69% of the infants, respectively. Compared to weaned, exclusively or partially breastfed infants were younger and had 46% higher tHcy concentrations (<jats:italic>P<\/jats:italic> &lt; 0.001), in addition to 47% and 39% lower cobalamin concentrations (<jats:italic>P<\/jats:italic> &lt; 0.001), respectively. However, the observed biomarker concentrations appeared to be independent of infant age. In conclusion, low vitamin B<jats:sub>12<\/jats:sub> status was prevalent and appeared to be more common in the younger exclusively breastfed compared to older weaned infants. The implications of low vitamin B<jats:sub>12<\/jats:sub> status in infancy are unknown and require further investigation.<\/jats:p>","DOI":"10.1017\/jns.2024.54","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T06:04:25Z","timestamp":1726725865000},"source":"Crossref","is-referenced-by-count":3,"title":["Breastfeeding and biomarkers of folate and cobalamin status in Norwegian infants: a cross-sectional study"],"prefix":"10.1017","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-0239","authenticated-orcid":false,"given":"Beate S.","family":"Solvik","sequence":"first","affiliation":[{"name":"Innlandet Hospital Trust"},{"name":"University of Bergen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjersti S.","family":"Bakken","sequence":"additional","affiliation":[{"name":"Innlandet Hospital Trust"},{"name":"University of Bergen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"McCann","sequence":"additional","affiliation":[{"name":"Innlandet Hospital Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M.","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-2688","authenticated-orcid":false,"given":"Sigrun","family":"Henjum","sequence":"additional","affiliation":[{"name":"Metropolitan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor A.","family":"Strand","sequence":"additional","affiliation":[{"name":"Innlandet Hospital Trust"},{"name":"University of Bergen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"S2048679024000545_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0072-2"},{"key":"S2048679024000545_ref43","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020546"},{"key":"S2048679024000545_ref36","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050639"},{"key":"S2048679024000545_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.751"},{"key":"S2048679024000545_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0567-x"},{"key":"S2048679024000545_ref54","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa111"},{"key":"S2048679024000545_ref26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02325"},{"key":"S2048679024000545_ref33","volume-title":"Spedkost 3. 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