{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T09:40:02Z","timestamp":1756719602287,"version":"3.44.0"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":243,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>This study examines the influence of fish oil on brain amyloidogenesis in hyperglycaemic Alzheimer\u2019s disease animal models, emphasising the potential of omega-3 fatty acids in fish oil to prevent the development of Alzheimer\u2019s disease. Thirty males of Wistar rats were divided into five groups: 1) control rats (NS); 2) rats supplemented with 3 g\/kg of fish oil (NS+FO3); 3)\u00a0rats injected via intraperitoneal (i.p) with Streptozotocin-Lipopolysaccharide (STZ-LPS); 4)\u00a0rats injected with STZ-LPS (i.p) and supplemented with 1 g\/kg of fish oil (STZ-LPS+FO1), and 5) rats injected with STZ-LPS (i.p) and supplemented with 3 g\/kg of fish oil (STZ-LPS+FO3). The cerebral brain was extracted for examination, and the \u03b1\u03b2 precursor protein (APP) level was measured using an immunoassay kit, while \u03b1\u03b2 42 expression was evaluated using immunohistochemistry staining. Brain amyloidosis-related genes were quantified using real-time Polymerase Chain Reaction (PCR). The results revealed that fish oil supplementation significantly increased APP levels and reduced \u03b1\u03b2 42 accumulations in STZ-LPS rats. Moreover, the Apolipoprotein E, \u03b54 isoform (ApoE-4) and Beta-site APP-cleaving enzyme 1 (Bace-1) genes were downregulated while the Low-density lipoprotein receptor-related protein 1 (Lrp-1) gene was upregulated in STZ-LPS rats treated with fish oil, thereby elucidating the impact of fish oil on diminishing \u03b1\u03b2 buildup in the brain. Therefore, this study contributes to a growing body of evidence supporting dietary interventions as adjunctive strategies for the prevention or delay of Alzheimer\u2019s disease progression in metabolic dysfunction.<\/jats:p>","DOI":"10.1017\/jns.2025.10036","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T09:02:29Z","timestamp":1756717349000},"source":"Crossref","is-referenced-by-count":0,"title":["Supplementation with fish oil reduces \u03b1\u03b2 42 burden and shifts \u03b1\u03b2 precursor protein processing toward non-amyloidogenic pathways in a rat model of hyperglycaemic Alzheimer\u2019s disease"],"prefix":"10.1017","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-3140","authenticated-orcid":false,"given":"Nurina","family":"Titisari","sequence":"first","affiliation":[{"name":"Universiti Putra Malaysia"},{"name":"Universitas Brawijaya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-7936","authenticated-orcid":false,"given":"Ahmad","family":"Fauzi","sequence":"additional","affiliation":[{"name":"Universitas Brawijaya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-3621","authenticated-orcid":false,"given":"Intan Shameha Abdul","family":"Razak","sequence":"additional","affiliation":[{"name":"Universiti Putra Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-9826","authenticated-orcid":false,"given":"Nurdiana","family":"Samsulrizal","sequence":"additional","affiliation":[{"name":"Universiti Teknologi MARA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-9863","authenticated-orcid":false,"given":"Hafandi","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Universiti Putra Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"S2048679025100360_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1368-x"},{"key":"S2048679025100360_ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"S2048679025100360_ref22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5923\/j.ajmms.20120203.04","article-title":"Oral administration of aqueous leaf extract of ocimum gratissimum ameliorates polyphagia, polydipsia and weight loss in streptozotocin-induced diabetic rats","volume":"2","author":"Uduak Akpan","year":"2012","journal-title":"Am J Med Med Sci."},{"key":"S2048679025100360_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.020"},{"key":"S2048679025100360_ref19","unstructured":"19. 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