{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:13:18Z","timestamp":1785417198866,"version":"3.56.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite the multiple advantages of 25-hydroxyvitamin D (calcifediol or 25(OH)D) compared to cholecalciferol, it is used sparingly. This study was planned to assess the safety and efficacy of supplementing daily 25 \u00b5g of calcifediol capsules vis-a-vis 100 \u00b5g (4000 IU) of cholecalciferol sachets in apparently healthy individuals with vitamin D deficiency in Chandigarh, India (latitude 30.7\u00b0 North, 76.8\u00b0 East). It was a prospective, interventional study to evaluate the effects of calcifediol vis-a-vis cholecalciferol. Following initial screening of 70 subjects in each group, 62 were included in the calcifediol and 41 in the cholecalciferol group. Forty-six from calcifediol and 37 from cholecalciferol group completed the 6-month follow up. There was a significant increase in serum 25(OH)D (355% in cholecalciferol &amp; 574% in calcifediol groups, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and 1,25 (OH)\n                    <jats:sub>2<\/jats:sub>\n                    D (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) with a marked decrease in iPTH (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and ALP (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.016) in both groups. Though serum ALP decreased significantly more in the calcifediol group than the cholecalciferol group, no appreciable difference in other biochemical parameters was noted between the groups. No episodes of hypercalcaemia or incidence of new renal stone disease were observed during follow-up. However, hypercalciuria (spot urine calcium creatinine &gt; 0.2 mg\/mg) was noted in 8\/46 individuals in the calcifediol group and 5\/37 individuals in the cholecalciferol group at final visit with no significant difference between two groups. This study establishes the efficacy and safety of correcting vitamin D deficiency with daily 25 \u00b5g calcifediol capsules as an alternative to 4000 IU (100 \u00b5g) cholecalciferol sachets.\n                  <\/jats:p>","DOI":"10.1017\/jns.2025.10064","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:25:38Z","timestamp":1766132738000},"source":"Crossref","is-referenced-by-count":0,"title":["An open-label interventional study on efficacy and safety of 25 \u00b5g of daily calcifediol capsule versus 100 \u00b5g of cholecalciferol sachets in apparently healthy volunteers"],"prefix":"10.1017","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6893-2211","authenticated-orcid":false,"given":"Ravi","family":"Shah","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009nfym65","id-type":"ROR","asserted-by":"publisher"}],"name":"Post Graduate Institute of Medical Education and Research (PGIMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9701-9554","authenticated-orcid":false,"given":"Liza","family":"Das","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009nfym65","id-type":"ROR","asserted-by":"publisher"}],"name":"Post Graduate Institute of Medical Education and Research (PGIMER)"},{"name":"PGIMER"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipika","family":"Bansal","sequence":"additional","affiliation":[{"name":"National Institute of Pharmaceutical Education and Research (NIPER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Sachdeva","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009nfym65","id-type":"ROR","asserted-by":"publisher"}],"name":"Post Graduate Institute of Medical Education and Research (PGIMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Holick","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-1611","authenticated-orcid":false,"given":"Pinaki","family":"Dutta","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/009nfym65","id-type":"ROR","asserted-by":"publisher"}],"name":"Post Graduate Institute of Medical Education and Research (PGIMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Medenica","sequence":"additional","affiliation":[{"name":"University of Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-8766","authenticated-orcid":false,"given":"Raman Kumar","family":"Marwaha","sequence":"additional","affiliation":[{"name":"Adolescents and Children (SEHEAC)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"S2048679025100645_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.11.022"},{"key":"S2048679025100645_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-008-0868-y"},{"key":"S2048679025100645_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.03.029"},{"key":"S2048679025100645_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.01.014"},{"key":"S2048679025100645_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03103-1"},{"key":"S2048679025100645_ref11","first-page":"6660","article-title":"Scientific opinion on the safety of calcidiol monohydrate produced by chemical synthesis as a novel food pursuant to regulation (EU)","volume":"19","author":"Turck","year":"2024","journal-title":"EFSA Journal"},{"key":"S2048679025100645_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz209"},{"key":"S2048679025100645_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2023.106248"},{"key":"S2048679025100645_ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000529523"},{"key":"S2048679025100645_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.551"},{"key":"S2048679025100645_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.10.014"},{"key":"S2048679025100645_ref16","unstructured":"16. Kunz, I , Beck, M , Schoop, R , Etheve, S et al. Leatherhead final study report: Response of serum 25-hydroxyvitamin D to different doses of calcifediol 0.25 SD\/Scompared to vitamin D3 supplementation: A randomized, controlled, double blind, tong term pharmacokinetic study [DSM Proprietary unpublished data]. 2016."},{"key":"S2048679025100645_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.12.020"},{"key":"S2048679025100645_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.50681"},{"key":"S2048679025100645_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01779-7"},{"key":"S2048679025100645_ref27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/2230-8210.196007","article-title":"Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency","volume":"21","author":"Gupta","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"key":"S2048679025100645_ref28","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061617"},{"key":"S2048679025100645_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09527-7"},{"key":"S2048679025100645_ref1","first-page":"118","article-title":"Vitamin D: The \u201csunshine\u201d vitamin","volume":"3","author":"Nair","year":"2012","journal-title":"J Pharmacol Pharmacother"},{"key":"S2048679025100645_ref21","unstructured":"21. Wittwer, J. Dose finding study in physically non-frail and (pre-)frail elderly to measure 25(OH) vitamin D levels after supplementation with HY.D calcifediol 25 SD\/S and vitamin D3 (D- dose study) [DSM Proprietary unpublished data]. 2015."},{"key":"S2048679025100645_ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3919"},{"key":"S2048679025100645_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4520-y"},{"key":"S2048679025100645_ref12","first-page":"1","article-title":"A. Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate","volume":"21","author":"Turck","year":"2023","journal-title":"EFSA Journal"},{"key":"S2048679025100645_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4180-3"},{"key":"S2048679025100645_ref22","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.ijp_873_22"},{"key":"S2048679025100645_ref26","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.031427"},{"key":"S2048679025100645_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03662-z"},{"key":"S2048679025100645_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3427-0"},{"key":"S2048679025100645_ref10","first-page":"e8520","article-title":"Scientific and technical assistance to the evaluation of the safety of calcidiol monohydrate as a novel food","volume":"22","author":"Turck","year":"2024","journal-title":"EFSA Journal"},{"key":"S2048679025100645_ref23","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.4.287"}],"container-title":["Journal of Nutritional Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2048679025100645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:25:40Z","timestamp":1766132740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2048679025100645\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":30,"alternative-id":["S2048679025100645"],"URL":"https:\/\/doi.org\/10.1017\/jns.2025.10064","relation":{},"ISSN":["2048-6790"],"issn-type":[{"value":"2048-6790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"article-number":"e1"}}