{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:18:03Z","timestamp":1785435483171,"version":"3.56.0"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"unspecified","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Monocrotaline (MCT) induces lung injury and pulmonary hypertension (PH) by a mechanism that is in part due to oxidative stress. The purpose of this study was to determine how MCT affected nutrient antioxidants retinol and alpha-tocopherol in a rat lung and liver. Rats were fed a purified diet (AIN-93G) one-week prior to a subcutaneous injection of MCT (60 mg\/kg) and remained on the diet throughout the study. Three weeks after injection, the animals were euthanized, and the lungs and livers were analyzed for retinol, alpha-tocopherol, phospholipid (PL), and cholesterol content. Lung retinol concentrations were significantly lower in MCT-treated rats, 2.0 \u00b1 1.2 (nmol\/g lung) vs. vehicle control (VEH), 5.8 \u00b1 1.4 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). However, liver retinol concentrations were not significantly different, 3.3 \u00b1 1.3 vs. 2.5 \u00b1 0.9 nmol\/g liver. Alpha-tocopherol was significantly greater in MCT-treated rats in the lung, 145 \u00b1 24 vs. 99 \u00b1 13 nmol\/g lung (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), and liver, 107 \u00b1 30 vs. 47.7 \u00b1 4.8 nmol\/g liver (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Phospholipid and cholesterol were significantly lower in the lung of the MCT-treated group, but not significantly different in the liver. In conclusion, retinol along with phospholipid, and cholesterol were decreased in the lungs whereas alpha-tocopherol was elevated in the lungs and liver in response to MCT. These findings along with others suggest a novel mechanistic link between MCT-induced oxidative stress, lung vitamin A depletion, inflammation and the impairment of alveolar cell proliferation and repair. Pulmonary retinol is important in the pathogenesis of MCT-induced lung injury.\n                  <\/jats:p>","DOI":"10.1017\/jns.2026.10077","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:09:11Z","timestamp":1770354551000},"source":"Crossref","is-referenced-by-count":0,"title":["Monocrotaline toxicity in rats: decreased lung retinol and elevated alpha-tocopherol levels in lung and liver"],"prefix":"10.1017","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-3488","authenticated-orcid":false,"given":"Richard Carleton","family":"Baybutt","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05p1j8758","id-type":"ROR","asserted-by":"publisher"}],"name":"Kansas State University"},{"id":[{"id":"https:\/\/ror.org\/0581k0452","id-type":"ROR","asserted-by":"publisher"}],"name":"Wheaton College"},{"id":[{"id":"https:\/\/ror.org\/01vx35703","id-type":"ROR","asserted-by":"publisher"}],"name":"East Carolina 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