{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:23:41Z","timestamp":1790115821027,"version":"4.0.1"},"reference-count":70,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"unspecified","delay-in-days":158,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We examined whether diet quality is associated with executive function (EF) in middle-aged women with a family history of Alzheimer\u2019s disease (AD) and whether this is moderated by a genetic AD risk factor, APOE-\u03b54 allele carriage. Data from 102 low-physically active women (\n                    <jats:italic>\n                      Age\n                      <jats:sub>Mean<\/jats:sub>\n                    <\/jats:italic>\n                    = 56.9 \u00b1 5.8 years) were analyzed cross-sectionally. Diet quality was quantified via the Healthy Eating Index-2020 (HEI-2020). Overall EF and sub-domains (working memory [WM], exogenous inhibitory control [ICex], endogenous inhibitory control [ICen], and cognitive flexibility) were measured using neurocognitive assessments. APOE-\u03b54 carriage was determined from saliva. Moderated regression models tested HEI-2020*APOE-\u03b54 interactions; significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; .05) and near-significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; .10) interactions were followed by simple slope analyses. Main effects of HEI-2020 predicted overall EF (\n                    <jats:italic>p<\/jats:italic>\n                    = .033) and WM (\n                    <jats:italic>p<\/jats:italic>\n                    = .003). Interaction effects of HEI-2020*APOE-\u03b54 for EF and WM (\n                    <jats:italic>p\u2019s<\/jats:italic>\n                    = .056\u2013.038) were such that diet quality was positively associated with overall EF (\n                    <jats:italic>p<\/jats:italic>\n                    = .003) and WM (\n                    <jats:italic>p<\/jats:italic>\n                    = .005) in noncarriers only. Main effects of select HEI-2020 sub-scores were observed for overall EF and sub-domains (\n                    <jats:italic>p\u2019s<\/jats:italic>\n                    = .001\u2013.047). Interaction effects of total vegetables*APOE-\u03b54 on overall EF and ICex, saturated fatty acids*APOE-\u03b54 on overall EF and WM, and added sugars*APOE-\u03b54 on ICen (\n                    <jats:italic>p\u2019s<\/jats:italic>\n                    = .007\u2013.074) were such that sub-scores were positively associated with cognition in noncarriers only (\n                    <jats:italic>p\u2019s<\/jats:italic>\n                    &lt; .05). Diet quality and select sub-scores were positively associated with EF in middle-aged women without APOE-\u03b54 only. Future work should explore if APOE-\u03b54 carriers require a threshold of diet quality to yield cognitive benefits.\n                  <\/jats:p>","DOI":"10.1017\/jns.2026.10106","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:21:13Z","timestamp":1780906873000},"source":"Crossref","is-referenced-by-count":1,"title":["APOE-\u03b54 moderates the association between diet quality and executive function in middle-aged women at increased risk for Alzheimer\u2019s disease"],"prefix":"10.1017","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1344-2037","authenticated-orcid":false,"given":"Chadsley M.","family":"Wessinger","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fnxsj42","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of North Carolina at Greensboro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Shin","family":"Park","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"DuBois","sequence":"additional","affiliation":[{"name":"Appalachian State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Wideman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fnxsj42","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of North Carolina at Greensboro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany D.","family":"Armstrong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fnxsj42","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of North Carolina at Greensboro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarod C.","family":"Vance","sequence":"additional","affiliation":[{"name":"Longwood University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Kibildis","sequence":"additional","affiliation":[{"name":"Athens-Clarke County Unified Government"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadassah","family":"Som-Pimpong","sequence":"additional","affiliation":[{"name":"Meharry Medical College School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Etnier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04fnxsj42","id-type":"ROR","asserted-by":"publisher"}],"name":"The University of North Carolina at Greensboro"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"S2048679026101062_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2019.107180"},{"key":"S2048679026101062_ref51","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666141212122352"},{"key":"S2048679026101062_ref12","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11020147"},{"key":"S2048679026101062_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igad104.3626"},{"key":"S2048679026101062_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3599"},{"key":"S2048679026101062_ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"S2048679026101062_ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01732-1"},{"key":"S2048679026101062_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2494"},{"key":"S2048679026101062_ref21","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.16.2.254"},{"key":"S2048679026101062_ref47","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1977.44.2.367"},{"key":"S2048679026101062_ref18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.2.355"},{"key":"S2048679026101062_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa023"},{"key":"S2048679026101062_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01806-7"},{"key":"S2048679026101062_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"S2048679026101062_ref2","unstructured":"2. 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