{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:26:53Z","timestamp":1785421613357,"version":"3.56.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"unspecified","delay-in-days":166,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nutr Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this cross-sectional study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)VitD], disease severity, nutritional and functional status in individuals with advanced chronic liver disease (ACLD). Clinical assessment included Child-Pugh, Model for End-Stage Liver Disease-Sodium (MELD-Na), and MELD 3.0 scores, as well as the presence of ascites. Nutritional status was assessed using disease-specific screening tools, anthropometry, body composition measures, including Dual-Energy X-ray Absorptiometry (DXA), sarcopenia and Liver Frailty Index (LFI). A total of 47 outpatients with ACLD were evaluated. 25(OH)VitD insufficiency (&lt;30 ng\/mL) prevalence was 76.6%. After multivariate adjustment, insufficiency was significantly associated with Child-Pugh B\/C (OR = 8.247;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.013), ascites (OR = 15.382;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.016), and nutritional risk by RFH-NPT (OR = 13.168;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.015). No independent associations were found with sarcopenia or frailty. Notably, ascites emerged as the pivotal link between clinical decompensation and nutritional vulnerability; its presence is a primary RFH-NPT criterion, which remained the only nutritional marker independently associated with vitamin D depletion. In conclusion, 25(OH)VitD insufficiency was associated with advanced disease severity and nutritional vulnerability. Patients at nutritional risk had 13.2 times higher odds of 25(OH)VitD insufficiency, while those with ascites and Child-Pugh B\/C showed 15.4 and 8.2 times higher odds, respectively. These findings emphasise that 25(OH)VitD levels are more closely linked to early nutritional risk than to established sarcopenia and frailty in this population.\n                  <\/jats:p>","DOI":"10.1017\/jns.2026.10113","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:16:28Z","timestamp":1781698588000},"source":"Crossref","is-referenced-by-count":0,"title":["Low 25(OH)Vitamin D levels are associated with nutritional risk and disease severity in outpatient individuals with advanced chronic liver disease"],"prefix":"10.1017","volume":"15","author":[{"given":"Josile Maria da Concei\u00e7\u00e3o","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Israel","family":"Rodrigues Junior","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dna7t83","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryana Isabelle de Almeida Neves","family":"Siqueira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dna7t83","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C\u00e9lia de Farias","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Ara\u00fajo de","family":"Barros-Neto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dna7t83","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0297","authenticated-orcid":false,"given":"Nassib Bezerra","family":"Bueno","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dna7t83","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-0193","authenticated-orcid":false,"given":"Fabiana Andr\u00e9a","family":"Moura","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00dna7t83","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Alagoas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"S204867902610113X_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12900"},{"key":"S204867902610113X_ref16","first-page":"e230146","article-title":"Maximum handgrip strength test in long-lived elderly people from Southeastern Brazil: Definition of cutoff points","volume":"26","author":"Machado","year":"2023","journal-title":"Rev Bras Geriatr Gerontol"},{"key":"S204867902610113X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.024"},{"key":"S204867902610113X_ref6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810705"},{"key":"S204867902610113X_ref28","doi-asserted-by":"publisher","DOI":"10.31393\/reports-vnmedical-2023-27(1)-15"},{"key":"S204867902610113X_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.1989.tb00034.x"},{"key":"S204867902610113X_ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1376217"},{"key":"S204867902610113X_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"S204867902610113X_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(21)00452-8"},{"key":"S204867902610113X_ref13","first-page":"1","article-title":"Obesity: Preventing and managing the global epidemic","volume":"894","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"S204867902610113X_ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01042"},{"key":"S204867902610113X_ref19","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041249"},{"key":"S204867902610113X_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cld.851"},{"key":"S204867902610113X_ref15","doi-asserted-by":"publisher","DOI":"10.1590\/0102-311xen155624"},{"key":"S204867902610113X_ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6665893"},{"key":"S204867902610113X_ref24","first-page":"6908","article-title":"Effect of vitamin D supplementation in patients with liver cirrhosis having spontaneous bacterial peritonitis: A randomized controlled study","volume":"25","author":"Mohamed","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"S204867902610113X_ref4","doi-asserted-by":"publisher","DOI":"10.36347\/sjams.2023.v11i08.015"},{"key":"S204867902610113X_ref21","doi-asserted-by":"publisher","DOI":"10.21608\/bjas.2022.221132"},{"key":"S204867902610113X_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2024.06.055"},{"key":"S204867902610113X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2022.06.005"},{"key":"S204867902610113X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.140"},{"key":"S204867902610113X_ref18","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11456"},{"key":"S204867902610113X_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13485"},{"key":"S204867902610113X_ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.660498"},{"key":"S204867902610113X_ref1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i6.1718"},{"key":"S204867902610113X_ref29","first-page":"CD011564","article-title":"Vitamin D supplementation for chronic liver diseases in adults","volume":"8","author":"Bjelakovic","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"S204867902610113X_ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6669527"},{"key":"S204867902610113X_ref17","first-page":"292","article-title":"Evaluating sarcopenia and nutritional status in outpatients with liver cirrhosis: Concordance of diagnostic methods","volume":"42","author":"Gischewski","year":"2025","journal-title":"Nutr Hosp"},{"key":"S204867902610113X_ref20","doi-asserted-by":"publisher","DOI":"10.59556\/japi.72.0352"}],"container-title":["Journal of Nutritional Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S204867902610113X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:16:29Z","timestamp":1781698589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S204867902610113X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":29,"alternative-id":["S204867902610113X"],"URL":"https:\/\/doi.org\/10.1017\/jns.2026.10113","relation":{},"ISSN":["2048-6790"],"issn-type":[{"value":"2048-6790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e44"}}