{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:05:54Z","timestamp":1784750754291,"version":"3.55.0"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":6342,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hookworms are known to cause marked changes to the intestinal mucosa, especially in relation to erosion of the villi. However, since the development of enteropathy has not been examined thoroughly through quantitative experiments on infected animals, the results of experiments conducted in hamsters infected with <jats:italic>Ancylostoma ceylanicum<\/jats:italic> are reported. Changes to intestinal architecture were first apparent between 12 and 14 days after infection, and then increased in intensity for 3\u20134 weeks, persisting for as long as worms were present (&gt;63 days). Following infection, the height of villi declined from a mean of 1002 \u03bcm in na\u00efve controls to less than 200 \u03bcm and as low as 18 \u03bcm in one case. The depth of the crypts of Lieberkuhn increased from a baseline value of 166 \u03bcm in na\u00efve controls to in excess of 600 \u03bcm within 6 weeks of infection. Mitotic figures had a baseline value of 5.5 per villus-crypt unit, and this rose to in excess of 25 in some experiments. Changes were dependent on the intensity of the parasite burden on day 20, but by 30 days after infection changes in all three values were maximal and density-dependent relationships were no longer clearly apparent. Villus height and crypt depth returned to near normal values within a week of the removal of worms, although group means for both remained different from na\u00efve controls for at least 3 weeks after treatment. Cellular division, as reflected in numbers of mitotic figures, stayed elevated for over 5 weeks after removal of worms. The results suggest that enteropathy in hookworm infections stems from a combination of intestinal immune responses and from the grazing activities of the adult worms on the mucosal surface, but is not sufficient <jats:italic>per se<\/jats:italic> for expulsion of this parasite.<\/jats:p>","DOI":"10.1017\/joh2006372","type":"journal-article","created":{"date-parts":[[2006,12,2]],"date-time":"2006-12-02T14:39:50Z","timestamp":1165070390000},"page":"397-407","source":"Crossref","is-referenced-by-count":9,"title":["The effect of the hookworm <i>Ancylostoma ceylanicum<\/i> on the mucosal architecture of the small intestine in hamsters"],"prefix":"10.1017","volume":"80","author":[{"given":"L.M.M.","family":"Alkazmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Dehlawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"S0022149X0070438X_ref037","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60552-7"},{"key":"S0022149X0070438X_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000075272"},{"key":"S0022149X0070438X_ref034","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3207"},{"key":"S0022149X0070438X_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(62)80096-1"},{"key":"S0022149X0070438X_ref017","volume-title":"Some methods for the statistical analysis of samples of benthic invertebrates","author":"Elliott","year":"1977"},{"key":"S0022149X0070438X_ref006","first-page":"507","article-title":"Invasion of the wall of the human intestine by ancylostomes","volume":"22","author":"Bonne","year":"1942","journal-title":"American Journal of Medicine"},{"key":"S0022149X0070438X_ref001","unstructured":"Alkazmi, L.M.M. 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