{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:27:32Z","timestamp":1787239652549,"version":"build-2736575974"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec id=\"S0924270813000021_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Here, we examined the cingulum bundle, a long-range white matter tract mediating dorsal limbic connectivity, using diffusion tensor imaging (DTI) tractography, in children and adolescents with autism spectrum disorder (ASD) versus controls. We hypothesised that cingulum bundle microstructure would be altered in ASD, based on evidence implicating abnormal white matter connectivity in this disorder.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270813000021_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>DTI data were acquired for 19 ASD participants (IQ \u2a7e 70; 7\u201318 years; mean = 12.4 \u00b1 3.1) and 16 age-matched controls (7\u201318 years; mean = 12.3 \u00b1 3.6) on a 3 T magnetic resonance imaging system. Deterministic tractography was used to isolate the cingulum bundle. Left and right cingulum bundles were examined for differences in several DTI metrics in ASD children\/adolescents versus controls, including: fractional anisotropy (FA), mean, axial, and radial diffusivity.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270813000021_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Significant age \u00d7 group interaction effects were found for all DTI metrics (mean diffusivity: <jats:italic>F<\/jats:italic><jats:sub>1,28<\/jats:sub> = 9.5, <jats:italic>p<\/jats:italic> = 0.005, radial diffusivity: <jats:italic>F<\/jats:italic><jats:sub>1,28<\/jats:sub> = 7.8, <jats:italic>p<\/jats:italic> = 0.009, axial diffusivity: <jats:italic>F<\/jats:italic><jats:sub>1,28<\/jats:sub> = 5.2, <jats:italic>p<\/jats:italic> = 0.03, FA: <jats:italic>F<\/jats:italic><jats:sub>1,28<\/jats:sub> = 4.4, <jats:italic>p<\/jats:italic> = 0.04). Interaction effects were driven by increases in cingulum bundle diffusivity (mean, radial, and axial diffusivity), and decreased FA, in younger ASD participants within our sample versus controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270813000021_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Our results point to immature microstructural organisation of the cingulum bundle in ASD, particularly during the early years of life, with implications for limbic network synchronisation and complex socio-emotional performance.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2013.2","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T07:49:41Z","timestamp":1369208981000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":34,"title":["Altered cingulum bundle microstructure in autism spectrum disorder"],"prefix":"10.1017","volume":"25","author":[{"given":"Stephanie H.","family":"Ameis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Rockel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha","family":"Soorya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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