{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:07:40Z","timestamp":1777284460950,"version":"3.51.4"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,10,13]],"date-time":"2013-10-13T00:00:00Z","timestamp":1381622400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec id=\"S0924270814000271_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Brain-derived neurotrophic factor (BDNF) plays a critical role in brain plasticity processes and serum levels have been demonstrated to be altered in patients with different mental disorder including suicidal behaviour. The objective of this study was to examine the association between serum BDNF levels as a possible peripheral indicator of suicide behaviour in subjects suffering from depression, personality disorders (PDs) and adjustment disorders (ADs) with or without suicide attempt.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000271_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The research included 172 randomly selected individuals suffering from recurrent depressive disorder (RDD; F 33.2), emotionally unstable PD (F 60.3) and AD (F 43.2), with or without attempted suicide according to the criteria of the ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th Revision) and 60 phenotypically health control subjects. In the group of patients, 73% subjects took some form of psychopharmacotherapy. Serum BDNF levels were measured by enzyme linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000271_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Subjects with PD and AD with suicide attempts had significantly lower serum BDNF levels than those without suicide attempts. In groups of subjects with PD and AD, those taking psychopharmacotherapy had higher serum BDNF levels. In the group of subjects with RDD, there were no differences with respect to suicide attempts or psychopharmacotherapy. Logistical regression analysis was indicated that psychopharmcotherapy and serum BDNF levels statistically correlated with suicide attempts.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000271_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The lower levels of BDNF in subjects suffering from PD and AD with suicide attempts, suggest that the serum BDNF level is a potential marker of suicidal behaviour, independent of mental disorders.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2014.27","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T09:16:34Z","timestamp":1413191794000},"page":"356-363","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["Brain-derived neurotrophic factor as a suicide factor in mental disorders"],"prefix":"10.1017","volume":"26","author":[{"given":"Majda","family":"Grah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mate","family":"Mihanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedjeljka","family":"Ruljancic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branka","family":"Restek-Petrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Jelavic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,10,13]]},"reference":[{"key":"S0924270814000271_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.035"},{"key":"S0924270814000271_ref56","doi-asserted-by":"publisher","DOI":"10.3109\/07853890903485730"},{"key":"S0924270814000271_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.09.016"},{"key":"S0924270814000271_ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5215.2011.00560.x"},{"key":"S0924270814000271_ref52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2010.02113.x"},{"key":"S0924270814000271_ref51","volume-title":"The Maudsley prescribing guidelines in psychiatry","author":"Taylor","year":"2012"},{"key":"S0924270814000271_ref50","volume-title":"Essentials of clinical psychopharmacology","author":"Schatzberg","year":"2013"},{"key":"S0924270814000271_ref46","volume-title":"International Statistical Classification of Diseases and Related Health Problems 10th Revision","year":"2004"},{"key":"S0924270814000271_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.10.017"},{"key":"S0924270814000271_ref36","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.8.804"},{"key":"S0924270814000271_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(96)00024-9"},{"key":"S0924270814000271_ref47","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"S0924270814000271_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.10.008"},{"key":"S0924270814000271_ref3","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000020633.93430.db"},{"key":"S0924270814000271_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.11.005"},{"key":"S0924270814000271_ref19","doi-asserted-by":"crossref","unstructured":"Van De Kerkof NWA , Fekkes D , Van Der Heijden FMMA , Verhoeven WMA . 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