{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:05:20Z","timestamp":1791201920545,"version":"4.2.0"},"reference-count":111,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec id=\"S0924270814000301_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Although poor sleep accompanies depression, it is unknown which specific sleep abnormalities precede depression. This is similarly the case for depression developing during interferon-\u03b1 (IFN-\u03b1) therapy. Because vulnerability becomes evident in those who slept poorly before IFN-\u03b1, we prospectively determined which specific aspect of sleep could predict subsequent depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000301_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Two nights of polysomnography with quantitative electroencephalogram (EEG) were obtained in 24 adult, euthymic subjects \u2013 all subsequently treated with IFN-\u03b1 for hepatitis C. Every 2 weeks, a Beck Depression Inventory-II (BDI-II) score was obtained, and the maximal increase in BDI-II from pre-treatment baseline \u2013 excluding the sleep question \u2013 was determined.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000301_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The delta sleep ratio (DSR; an index of early-night restorative delta power) was inversely associated with BDI-II increases (<jats:italic>p<\/jats:italic>&lt;0.01), as was elevated alpha power (8\u201312 Hz; <jats:italic>p<\/jats:italic>&lt;0.001). Both delta (0.5\u20134 Hz) and alpha power exhibited high between-night correlations (<jats:italic>r<\/jats:italic>=0.83 and 0.92, respectively). In mixed-effect repeated-measure analyses, there was an interaction between alpha power and DSR (<jats:italic>p<\/jats:italic>&lt;0.001) \u2013 subjects with low alpha power and elevated DSR were resilient to developing depression. Most other sleep parameters \u2013 including total sleep time and percentage of time in slow wave sleep \u2013 were not associated with subsequent changes in depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000301_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Both high DSR and low alpha power may be specific indices of resilience. As most other aspects of sleep were not associated with resilience or vulnerability, sleep interventions to prevent depression may need to specifically target these specific sleep parameters.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2014.30","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T15:09:39Z","timestamp":1417446579000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["Decreased delta sleep ratio and elevated alpha power predict vulnerability to depression during interferon-alpha treatment"],"prefix":"10.1017","volume":"27","author":[{"given":"Francis 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