{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:15:48Z","timestamp":1776986148711,"version":"3.51.4"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec id=\"S0924270814000362_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Glucagon-like peptide 1 (GLP-1) receptor agonists are a new group of antidiabetic medications quickly gaining popularity. We aimed to examine behavioural and neuroendocrine changes following chronic treatment with GLP-1 receptor agonists in animal models.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000362_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The effects of chronic treatment with GLP-1 receptor agonists were determined on behavioural parameters [anxiety level in the light\u2013dark compartment test, the motor activity in automated activity cages, immobility in the forced swimming test (FST)] and on corticosterone release in mice. The possible antidepressant effect of chronic liraglutide treatment was also studied in Flinders Sensitive Line (FSL) rats, a genetic model of depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000362_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Two weeks of treatment with exenatide (10 \u00b5g \/kg twice daily) or liraglutide (1200 \u00b5g\/kg once daily) did not affect the anxiety level in a light\u2013dark compartment test nor induce an antidepressant-like effect in the FST in mice. Moreover, chronic treatment with liraglutide had no effect on depression-related behaviour in FSL rats. Interestingly, hypolocomotion induced by the drugs in mice disappeared after chronic dosing. Both of the GLP-1 receptor agonists induced robust increases in corticosterone levels in mice under basal conditions as well as in the case of combination with swimming stress. Remarkably, exenatide was as potent a stimulator of corticosterone release after 2 weeks as after acute administration.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270814000362_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The increases in corticosterone release seen after acute exenatide or liraglutide treatment do not abate after 2 weeks of treatment demonstrating that tolerance does not develop towards this particular effect of GLP-1 agonists.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2014.36","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T08:39:44Z","timestamp":1417595984000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":27,"title":["GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic 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