{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:11:05Z","timestamp":1791198665210,"version":"4.1.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec id=\"S0924270815000101_abs1\" sec-type=\"general\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Magnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000101_abs2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL\/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000101_abs3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000101_abs4\" sec-type=\"conclusion\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Magnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2015.10","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T06:28:23Z","timestamp":1426487303000},"page":"307-311","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":43,"title":["Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL\/6N mice"],"prefix":"10.1017","volume":"27","author":[{"given":"Bettina","family":"Pyndt J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Winther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Kihl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregers","family":"Wegener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel K.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte B.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"S0924270815000101_ref5","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v2.i1.13"},{"key":"S0924270815000101_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2013.06.004"},{"key":"S0924270815000101_ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010529108"},{"key":"S0924270815000101_ref17","unstructured":"Winther G . Magnesium deficiency induces anxiety- and depression-like behavior and metabolic dysfunction in C57Bl\/6 J mice, MSc Thesis, University of Aarhus, Denmark. 2012."},{"key":"S0924270815000101_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.10.051"},{"key":"S0924270815000101_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.01.006"},{"key":"S0924270815000101_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046231"},{"key":"S0924270815000101_ref15","first-page":"371","article-title":"Gastrointestinal microbiota and local inflammation during oxazolone-induced dermatitis in BALB\/cA mice","volume":"62","author":"Lundberg","year":"2012","journal-title":"Comp Med"},{"key":"S0924270815000101_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.01.047"},{"key":"S0924270815000101_ref9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063388"},{"key":"S0924270815000101_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(81)90007-1"},{"key":"S0924270815000101_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.08.010"},{"key":"S0924270815000101_ref19","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.117374"},{"key":"S0924270815000101_ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103398"},{"key":"S0924270815000101_ref16","doi-asserted-by":"publisher","DOI":"10.1023\/A:1000669317571"},{"key":"S0924270815000101_ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000268126"},{"key":"S0924270815000101_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.07.027"},{"key":"S0924270815000101_ref11","doi-asserted-by":"publisher","DOI":"10.4161\/cib.15702"},{"key":"S0924270815000101_ref12","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002696"},{"key":"S0924270815000101_ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.052"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270815000101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T15:03:17Z","timestamp":1555772597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270815000101\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0924270815000101"],"URL":"https:\/\/doi.org\/10.1017\/neu.2015.10","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]},"assertion":[{"value":"\u00a9 Scandinavian College of Neuropsychopharmacology 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}