{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:08:57Z","timestamp":1790622537741,"version":"4.1.0"},"reference-count":113,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec id=\"S0924270815000125_abs1\" sec-type=\"general\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This paper reviews the magnetic resonance imaging (MRI) literature on the effects of prenatal alcohol exposure on the developing human brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000125_abs2\" sec-type=\"general\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A literature search was conducted through the following databases: PubMed, PsycINFO and Google Scholar. Combinations of the following search terms and keywords were used to identify relevant studies: \u2018alcohol\u2019, \u2018fetal alcohol spectrum disorders\u2019, \u2018fetal alcohol syndrome\u2019, \u2018FAS\u2019, \u2018FASD\u2019, \u2018MRI\u2019, \u2018DTI\u2019, \u2018MRS\u2019, \u2018neuroimaging\u2019, \u2018children\u2019 and \u2018infants\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000125_abs3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 64 relevant articles were identified across all modalities. Overall, studies reported smaller total brain volume as well as smaller volume of both the white and grey matter in specific cortical regions. The most consistently reported structural MRI findings were alterations in the shape and volume of the corpus callosum, as well as smaller volume in the basal ganglia and hippocampi. The most consistent finding from diffusion tensor imaging studies was lower fractional anisotropy in the corpus callosum. Proton magnetic resonance spectroscopy studies are few to date, but showed altered neurometabolic profiles in the frontal and parietal cortex, thalamus and dentate nuclei. Resting-state functional MRI studies reported reduced functional connectivity between cortical and deep grey matter structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000125_abs4\" sec-type=\"discussion\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>There is a critical gap in the literature of MRI studies in alcohol-exposed children under 5 years of age across all MRI modalities. The dynamic nature of brain maturation and appreciation of the effects of alcohol exposure on the developing trajectory of the structural and functional network argue for the prioritisation of studies that include a longitudinal approach to understanding this spectrum of effects and potential therapeutic time points.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2015.12","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T11:50:00Z","timestamp":1426593000000},"page":"251-269","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":179,"title":["Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review"],"prefix":"10.1017","volume":"27","author":[{"given":"Kirsten Ann","family":"Donald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Eastman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur Margaret","family":"Howells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Adnams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Patrick","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Paul","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Louise","family":"Narr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Joseph","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,3,17]]},"reference":[{"key":"S0924270815000125_ref68","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20747"},{"key":"S0924270815000125_ref63","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"S0924270815000125_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.07.068"},{"key":"S0924270815000125_ref62","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2427-x"},{"key":"S0924270815000125_ref89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01046.x"},{"key":"S0924270815000125_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.026"},{"key":"S0924270815000125_ref32","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21313"},{"key":"S0924270815000125_ref52","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm039"},{"key":"S0924270815000125_ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-007-9013-0"},{"key":"S0924270815000125_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12051"},{"key":"S0924270815000125_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agr029"},{"key":"S0924270815000125_ref75","first-page":"1840","volume-title":"Clinical magnetic resonance imaging","author":"Ross","year":"2006"},{"key":"S0924270815000125_ref40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01951.x"},{"key":"S0924270815000125_ref88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01880.x"},{"key":"S0924270815000125_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30015"},{"key":"S0924270815000125_ref96","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12017"},{"key":"S0924270815000125_ref72","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1056"},{"key":"S0924270815000125_ref56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01679.x"},{"key":"S0924270815000125_ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.09.017"},{"key":"S0924270815000125_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2006.08.002"},{"key":"S0924270815000125_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.029"},{"key":"S0924270815000125_ref99","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1530-0277.2010.01230.x","article-title":"An FMRI study of number processing in children with fetal alcohol syndrome","volume":"34","author":"Meintjes","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"S0924270815000125_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00188.x"},{"key":"S0924270815000125_ref76","first-page":"760","article-title":"Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders","volume":"27","author":"Astley","year":"2009","journal-title":"J Magn Reson"},{"key":"S0924270815000125_ref60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5067-07.2008"},{"key":"S0924270815000125_ref3","unstructured":". 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