{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:15:28Z","timestamp":1774869328340,"version":"3.50.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec id=\"S0924270815000046_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Chronic inflammation is implicated in numerous diseases, including major depression and type 2 diabetes mellitus (T2DM). Since depression and T2DM often co-exist, inflammatory pathways are suggested as a possible link. Hence, the establishment of an immune-mediated animal model would shed light on mechanisms possibly linking depression and metabolic alterations.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270815000046_abs2\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>In this study we investigated a behavioural and metabolic paradigm following chronic infusion with low doses of lipopolysaccharide (LPS) using osmotic minipumps in male rats.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270815000046_abs3\" sec-type=\"general\"><jats:title>Methods<\/jats:title><jats:p>Behavioural testing consisted of evaluating activity level in the open field and depressive-like behaviour in the forced swim test. Metabolic assessment included measurement of body weight, food and water intake, and glucose and insulin levels during an oral glucose tolerance test.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270815000046_abs4\" sec-type=\"general\"><jats:title>Results<\/jats:title><jats:p>LPS-infused rats showed acute signs of sickness behaviour, but chronic LPS infusion did not induce behavioural or metabolic changes.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270815000046_abs5\" sec-type=\"general\"><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that although inflammation is immediately induced as indicated by acute sickness, 4 weeks of chronic LPS administration via osmotic minipumps did not result in behavioural changes. Therefore, this paradigm may not be a suitable model for studying the underlying mechanisms that link depression and T2DM.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2015.4","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T09:31:58Z","timestamp":1424424718000},"page":"189-194","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Chronic lipopolysaccharide infusion fails to induce depressive-like behaviour in adult male rats"],"prefix":"10.1017","volume":"27","author":[{"given":"Christina Weide","family":"Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-8911","authenticated-orcid":false,"given":"Nico","family":"Liebenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne 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