{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:08:22Z","timestamp":1787317702334,"version":"build-2736575974"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec id=\"S0924270815000502_abs1\" sec-type=\"general\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      11\u03b2-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids\n                      <jats:italic>in vivo<\/jats:italic>\n                      , respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 \u03b2-HSD1 in animal tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000502_abs2\" sec-type=\"general\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed 11 \u03b2-HSD1 knockout mice in the forced swim test (FST), tail suspension test (TST) and for locomotor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000502_abs3\" sec-type=\"general\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Genetic ablation of the 11\u03b2-HSD1 gene results in an antidepressant-like phenotype in the FST; the most widely utilised animal test of antidepressant activity, but not in the related TST. This may be related to the different biological substrates underlying these tests. The decreased FST immobility was not due to alterations in general activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270815000502_abs4\" sec-type=\"general\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together these results suggest that 11\u03b2-HSD1 may play an important role in depression-related behaviours and further studies are necessary to fully characterise its role in such behaviour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2015.50","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T22:53:38Z","timestamp":1443048818000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["11-\u03b2 hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test"],"prefix":"10.1017","volume":"28","author":[{"given":"David A.","family":"Slattery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doncho P.","family":"Uzunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"S0924270815000502_ref19","first-page":"73","volume-title":"Experimental approaches to anxiety and depression","author":"Porsolt","year":"1992"},{"key":"S0924270815000502_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.009"},{"key":"S0924270815000502_ref11","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.1.7887"},{"key":"S0924270815000502_ref20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14924"},{"key":"S0924270815000502_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.03.014"},{"key":"S0924270815000502_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001873"},{"key":"S0924270815000502_ref9","doi-asserted-by":"publisher","DOI":"10.2174\/0929867054020945"},{"key":"S0924270815000502_ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000331345"},{"key":"S0924270815000502_ref7","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1626"},{"key":"S0924270815000502_ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02667.x"},{"key":"S0924270815000502_ref8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00017.2005"},{"key":"S0924270815000502_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.329"},{"key":"S0924270815000502_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00236-0"},{"key":"S0924270815000502_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300413"},{"key":"S0924270815000502_ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0601"},{"key":"S0924270815000502_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00159-7"},{"key":"S0924270815000502_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01088-X"},{"key":"S0924270815000502_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.033"},{"key":"S0924270815000502_ref16","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"S0924270815000502_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001457"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270815000502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T18:11:56Z","timestamp":1555697516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270815000502\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,24]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0924270815000502"],"URL":"https:\/\/doi.org\/10.1017\/neu.2015.50","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,24]]},"assertion":[{"value":"\u00a9 Scandinavian College of Neuropsychopharmacology 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}