{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:16:27Z","timestamp":1792552587570,"version":"4.5.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec id=\"S0924270816000132_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the dynamic thiol\u2013disulphide homeostasis as an oxidative stress parameter, using a newly proposed method, in patients with Alzheimer\u2019s disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000132_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>In total, 97 participants were included in the study. Among them, 51 had been diagnosed with Alzheimer\u2019s disease, and the remaining 46 were healthy individuals. Total thiol (\u2013SH+\u2013S\u2013S\u2013) levels and native thiol (\u2013SH) levels in serum of each participant were measured. The amount of dynamic disulphide bonds (\u2013S\u2013S\u2013) and (\u2013S\u2013S\u2013) \u00d7100\/(\u2013SH), (\u2013S\u2013S\u2013) \u00d7100\/(\u2013SH+\u2013S\u2013S\u2013), and \u2013SH\u00d7100\/(\u2013SH+\u2013S\u2013S\u2013) ratios were calculated from these values. The obtained data were used to compare Alzheimer\u2019s disease patients with healthy individuals.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000132_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The average total thiol and native thiol levels of patient with Alzheimer\u2019s disease in the study were found to be significantly lower than those levels of healthy individuals. In addition, in the patient group, the \u2013S\u2013S\u2013\u00d7100\/\u2013S\u2013S+\u2013SH ratio was found to be significantly higher, whereas the \u2013SH\u00d7100\/\u2013S\u2013S+\u2013SH ratio was found to be significantly lower compared with healthy individuals. Total thiol and native thiol levels, dynamic disulphide bond amount, and \u2013S\u2013S\u2013\u00d7100\/\u2013SH, \u2013S\u2013S\u2013\u00d7100\/\u2013S\u2013S+\u2013SH, and \u2013SH\u00d7100\/\u2013S\u2013S+\u2013SH ratios were not found to be correlated with mini mental state examination score or duration of disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000132_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Recent studies have shown that oxidative stress is the one of the molecular changes underlying the pathogenesis of Alzheimer\u2019s disease. In this study, we have investigated the dynamic thiol\u2013disulphide homeostasis in patients with Alzheimer\u2019s disease, using a novel method.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2016.13","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T09:17:58Z","timestamp":1459761478000},"page":"315-320","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":48,"title":["A novel oxidative stress marker in patients with Alzheimer\u2019s disease: dynamic thiol\u2013disulphide homeostasis"],"prefix":"10.1017","volume":"28","author":[{"given":"Sadiye","family":"Gumusyayla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonul","family":"Vural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesna","family":"Bektas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Neselioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"S0924270816000132_ref20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10540"},{"key":"S0924270816000132_ref13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/ajcn\/72.2.653S","article-title":"Thiol homeostasis and supplements in physical exercise","volume":"72","author":"Sen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"S0924270816000132_ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.462929"},{"key":"S0924270816000132_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90018-3"},{"key":"S0924270816000132_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-012-9867-6"},{"key":"S0924270816000132_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01451-8"},{"key":"S0924270816000132_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.08.021"},{"key":"S0924270816000132_ref17","doi-asserted-by":"crossref","unstructured":"Mecocc\u0456 P , Macgarvey U , Beal M et al. 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