{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:43:14Z","timestamp":1787794994680,"version":"build-2784847793"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec id=\"S0924270816000168_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>For centuries, cannabinoids have been known to be effective in pain states. Itch and pain are two sensations sharing a lot in common.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000168_abs2\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>The goal of this research was to observe whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behaviour and whether neurotoxic destruction of descending serotonergic and noradrenergic pathways mediate the antipruritic effect of WIN 55,212-2.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000168_abs3\" sec-type=\"general\"><jats:title>Material and methods<\/jats:title><jats:p>Scratching behaviour was induced by intradermal injection of serotonin (50 \u00b5g\/50 \u00b5l\/mouse) to Balb\/c mice. The neurotoxins 5,7-dihydroxytryptamine (5,7-DHT, 50 \u03bcg\/mouse) and 6-hydroxydopamine (6-OHDA, 20 \u03bcg\/mouse) are applied intrathecally to deplete serotonin and noradrenaline in the spinal cord. WIN 55,212-2 (1, 3, 10 mg\/kg, i.p.) dose-dependently attenuated serotonin-induced scratches. Neurotoxic destruction of neither the serotonergic nor the noradrenergic systems by 5,7-DHT and 6-OHDA, respectively, had any effect on the antipruritic action of WIN 55,212-2.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000168_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that cannabinoids dose-dependently reduce serotonin-induced scratching behaviour and neurotoxic destruction of descending inhibitory pathways does not mediate this antipruritic effect.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2016.16","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T10:45:25Z","timestamp":1460457925000},"page":"321-326","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Descending serotonergic and noradrenergic systems do not regulate the antipruritic effects of cannabinoids"],"prefix":"10.1017","volume":"28","author":[{"given":"Zeynep 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