{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T12:22:49Z","timestamp":1725020569580},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec id=\"S0924270816000259_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-\u03b3+874 A\/T, TNF-\u03b1-308 G\/A, and IL-10-1082 G\/A single nucleotide polymorphisms (SNPs) to determine their association with PD.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000259_abs2\" sec-type=\"general\"><jats:title>Method<\/jats:title><jats:p>This study enroled 135 PD patients and 135 healthy controls. INF-\u03b3+874 A\/T (rs2430561), TNF-\u03b1-308 G\/A (rs1800629), and IL-10-1082 G\/A (rs1800896) were genotyped.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000259_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A\/G and G\/G genotype in the IL-10 SNP than the female patient group.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000259_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>We suggest that the G allele in IL-10-1082 G\/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2016.25","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T06:08:41Z","timestamp":1465193321000},"page":"357-361","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["The G allele in IL-10-1082 G\/A may have a role in lowering the susceptibility to panic disorder in female 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