{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:44:00Z","timestamp":1786999440122,"version":"build-2736575974"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec id=\"S0924270816000272_abs1\" sec-type=\"general\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study, we aimed to present the rates and clinical correlates of suicidal thoughts\/acts in patients recruited from a total of 40 centres in 10 Asian countries\/areas: China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Singapore, Taiwan, and Thailand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270816000272_abs2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from 1122 patients with depressive disorders in the REAP-AD study were used. The ICD-10 was employed to diagnose depressive episodes and recurrent depressive disorder. The presence or absence of suicidal thoughts\/acts and profile of other depressive symptoms was established using the National Institute for Health and Clinical Excellence guidelines for depression. Country\/area differences in rates of suicidal thoughts\/acts were evaluated with the \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test. In addition, depressive symptom profiles, other clinical characteristics, and patterns of psychotropic drug prescription in depressed patients with and without suicidal thoughts\/acts were compared using analysis of covariance for continuous variables and logistic regression analysis for discrete variables to adjust the effects of covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270816000272_abs3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rates of suicidal thoughts\/acts in 10 countries\/areas varied from 12.8% in Japan to 36.3% in China. Patients with suicidal thoughts\/acts presented more persistent sadness (adjusted odds ratio [aOR]=2.64,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), loss of interest (aOR=2.33,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), fatigue (aOR=1.58,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), insomnia (aOR=1.74,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), poor concentration (aOR=1.88,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), low self-confidence (aOR=1.78,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), poor appetite (aOR=2.27,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), guilt\/self-blame (aOR=3.03,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001), and use of mood stabilisers (aOR=1.79,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001) than those without suicidal thoughts\/acts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270816000272_abs4\" sec-type=\"conclusion\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Suicidal thoughts\/acts can indicate greater severity of depression, and are associated with a poorer response to antidepressants and increased burden of illness. Hence, suicidal thoughts\/acts can provide a clinical index reflecting the clinical status of depressive disorders in Asians.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2016.27","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T05:58:31Z","timestamp":1466056711000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":26,"title":["Suicidal thoughts\/acts and clinical correlates in patients with depressive disorders in Asians: results from the REAP-AD study"],"prefix":"10.1017","volume":"28","author":[{"given":"Seon-Cheol","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woo","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Mei","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Kanba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian-Yoon","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Kok","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pichet","family":"Udomratn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adarsh","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Sartorius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Shinfuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita M.","family":"Maramis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Chon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"S0924270816000272_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2000.00756.x"},{"key":"S0924270816000272_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.09.033"},{"key":"S0924270816000272_ref32","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130023"},{"key":"S0924270816000272_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511543609.010"},{"key":"S0924270816000272_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2007.06.012"},{"key":"S0924270816000272_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/appy.12170"},{"key":"S0924270816000272_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.05.036"},{"key":"S0924270816000272_ref17","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.5.719"},{"key":"S0924270816000272_ref23","doi-asserted-by":"publisher","DOI":"10.1521\/suli.32.4.347.22338"},{"key":"S0924270816000272_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/appy.12176"},{"key":"S0924270816000272_ref14","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14121590"},{"key":"S0924270816000272_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.01.006"},{"key":"S0924270816000272_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415579464"},{"key":"S0924270816000272_ref30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080030"},{"key":"S0924270816000272_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.11.002"},{"key":"S0924270816000272_ref33","doi-asserted-by":"publisher","DOI":"10.1177\/0004867412437346"},{"key":"S0924270816000272_ref15","volume-title":"The ICD-10 classification of mental and behavioral disorders, clinical descriptions and diagnostic guidelines","year":"1992"},{"key":"S0924270816000272_ref16","volume-title":"Depression in adults: the treatment and management of depression in adults","year":"2009"},{"key":"S0924270816000272_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2013.01.005"},{"key":"S0924270816000272_ref25","doi-asserted-by":"publisher","DOI":"10.1177\/136346150103800105"},{"key":"S0924270816000272_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/09638237.2013.799265"},{"key":"S0924270816000272_ref28","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.128694"},{"key":"S0924270816000272_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.047"},{"key":"S0924270816000272_ref1","doi-asserted-by":"publisher","DOI":"10.5124\/jkma.2012.55.4.322"},{"key":"S0924270816000272_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-37"},{"key":"S0924270816000272_ref37","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511543609.032"},{"key":"S0924270816000272_ref24","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.0223"},{"key":"S0924270816000272_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16066-2"},{"key":"S0924270816000272_ref4","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2015.12.3.281"},{"key":"S0924270816000272_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2014.11.003"},{"key":"S0924270816000272_ref12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4103\/0366-6999.154272","article-title":"Prevalence and prescription of antidepressants in depression with somatic comorbidity in Asia: the Research on East Asian Psychotropic Prescription Patterns Study","volume":"127","author":"Chen","year":"2015","journal-title":"Chin Med J"},{"key":"S0924270816000272_ref20","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.2014.77.4.360"},{"key":"S0924270816000272_ref2","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2014.11.3.232"},{"key":"S0924270816000272_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1999.tb00985.x"},{"key":"S0924270816000272_ref35","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/psyg.12048","article-title":"Predictors of length of hospital stay for patients with late-onset depression in Japan","volume":"14","author":"Mastumoto","year":"2014","journal-title":"Psychogeriatrics"},{"key":"S0924270816000272_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000019"},{"key":"S0924270816000272_ref9","first-page":"72","article-title":"Research on Asian Prescription Pattern (REAP): focusing on data from Japan","volume":"28","author":"Shinfuku","year":"2014","journal-title":"Taiwanese J Psychiatry"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270816000272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T16:25:07Z","timestamp":1555604707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270816000272\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0924270816000272"],"URL":"https:\/\/doi.org\/10.1017\/neu.2016.27","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]},"assertion":[{"value":"\u00a9 Scandinavian College of Neuropsychopharmacology 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}