{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:19:40Z","timestamp":1790651980180,"version":"4.1.0"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec id=\"S0924270816000491_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to report the frequency of autoimmune disorders and autoantibodies in 22 patients with neuromyelitis optica (NMO), as well as whether the seropositivity for autoantibodies differs between anti-aquaporin 4 (AQP4) positive and AQP4 negative NMO patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000491_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Demographic, medical records, and a profile of autoantibodies were evaluated in 22 NMO patients, including AQP4, anti-thyroid-stimulating hormone receptor, antinuclear antibodies (ANA), anti-thyroperoxidase (anti-TPO), anti-thyroglobulin (anti-Tg), anti-double-stranded DNA, anti-neutrophil cytoplasmic, anti-cyclic citrullinate peptide, rheumatoid factor, anti-SSA\/Ro, anti-SSB\/La, anti-Smith antibodies (anti-Sm), anti-ribonucleoprotein, anti-nucleosome, and anti-Scl70. Thyroid-stimulating hormone and free thyroxin were measured.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000491_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The frequency of women was higher than men (95.5% vs. 4.5%) and 68.2% were Afro-Brazilians. Six (27.3%) patients presented other autoimmune disorders, such as Hashimoto thyroiditis (<jats:italic>n<\/jats:italic>=2), Graves\u2019 disease (<jats:italic>n<\/jats:italic>=1), juvenile idiopathic arthritis (<jats:italic>n<\/jats:italic>=1), systemic lupus erythematosus and systemic sclerosis (<jats:italic>n<\/jats:italic>=1), and Raynaud\u2019s phenomenon (<jats:italic>n<\/jats:italic>=1). The most frequent autoantibodies were anti-AQP4 (54.5%), anti-nucleosome (31.8%), ANA (27.3%), anti-TPO (22.7%), and anti-Tg (22.7%). Difference was not observed in the frequency of autoimmune disorders when the patients were compared according to their anti-AQP4 status.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000491_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The results of the present study underscored that the NMO patients present high frequency of autoantibodies against cellular antigens and the presence of autoimmune disorders. Further studies with large number of NMO patients may contribute to advances in the understanding of NMO disease mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2016.49","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T04:37:56Z","timestamp":1475469476000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":39,"title":["Frequency of autoimmune disorders and autoantibodies in patients with neuromyelitis optica"],"prefix":"10.1017","volume":"29","author":[{"given":"Wild\u00e9a Lice de Carvalho Jennings","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna Maria Vissoci","family":"Reiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Kallaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayonara Rangel","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Name Colado","family":"Sim\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcell Alysson Batisti","family":"Lozovoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Jos\u00e9 Vaz","family":"Schiav\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Raquel do Vale Pascoal","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Frizon","family":"Alfieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires","family":"Flauzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damacio Ram\u00f3n","family":"Kaimen-Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"key":"S0924270816000491_ref50","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.6.934"},{"key":"S0924270816000491_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.01.011"},{"key":"S0924270816000491_ref29","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042009000100006"},{"key":"S0924270816000491_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.013"},{"key":"S0924270816000491_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/art.22540"},{"key":"S0924270816000491_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.09.374"},{"key":"S0924270816000491_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.02.018"},{"key":"S0924270816000491_ref34","first-page":"565","article-title":"Endocrine autoimmunity in young patients with juvenile chronic arthritis","volume":"20","author":"Alpigiani","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"S0924270816000491_ref39","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000100034"},{"key":"S0924270816000491_ref15","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.49.491"},{"key":"S0924270816000491_ref9","doi-asserted-by":"publisher","DOI":"10.1076\/noph.25.3.151.7133"},{"key":"S0924270816000491_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01416.x"},{"key":"S0924270816000491_ref48","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn240"},{"key":"S0924270816000491_ref51","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-470"},{"key":"S0924270816000491_ref35","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh531"},{"key":"S0924270816000491_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"S0924270816000491_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.045"},{"key":"S0924270816000491_ref56","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513483891"},{"key":"S0924270816000491_ref27","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"S0924270816000491_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.03.020"},{"key":"S0924270816000491_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-8"},{"key":"S0924270816000491_ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0781-2"},{"key":"S0924270816000491_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591"},{"key":"S0924270816000491_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1502-7"},{"key":"S0924270816000491_ref4","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.3.115"},{"key":"S0924270816000491_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.03.007"},{"key":"S0924270816000491_ref36","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000314832.24682.c6"},{"key":"S0924270816000491_ref55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2007.00483.x"},{"key":"S0924270816000491_ref40","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24617"},{"key":"S0924270816000491_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12087"},{"key":"S0924270816000491_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.02.023"},{"key":"S0924270816000491_ref45","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000300001"},{"key":"S0924270816000491_ref8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"S0924270816000491_ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300403"},{"key":"S0924270816000491_ref30","first-page":"280","article-title":"Transverse myelitis as the first manifestations of systemic lupus erythematosus or lupus-like disease: good functional outcome and relevance of antiphospholipid antibodies","volume":"31","author":"D\u2019cruz","year":"2004","journal-title":"J Rheumatol"},{"key":"S0924270816000491_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511403958"},{"key":"S0924270816000491_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32814f1c6b"},{"key":"S0924270816000491_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431728"},{"key":"S0924270816000491_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"S0924270816000491_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3066-3"},{"key":"S0924270816000491_ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0287-6"},{"key":"S0924270816000491_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"S0924270816000491_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-014-0162-7"},{"key":"S0924270816000491_ref52","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.6.795a"},{"key":"S0924270816000491_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.04.009"},{"key":"S0924270816000491_ref37","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-14"},{"key":"S0924270816000491_ref49","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.097972"},{"key":"S0924270816000491_ref47","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm062"},{"key":"S0924270816000491_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4857-7_8"},{"key":"S0924270816000491_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.17"},{"key":"S0924270816000491_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.01.002"},{"key":"S0924270816000491_ref23","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"S0924270816000491_ref28","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"S0924270816000491_ref42","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000240354.37927.dd"},{"key":"S0924270816000491_ref14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825644ff"},{"key":"S0924270816000491_ref46","first-page":"5","article-title":"Neuromyelitis optica pathogenesis and aquaporin 4","volume":"29","author":"Graber","year":"2008","journal-title":"J Neuroinflammation"},{"key":"S0924270816000491_ref16","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431077"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270816000491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T17:32:38Z","timestamp":1555522358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270816000491\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0924270816000491"],"URL":"https:\/\/doi.org\/10.1017\/neu.2016.49","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]},"assertion":[{"value":"\u00a9 Scandinavian College of Neuropsychopharmacology 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}