{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:07:30Z","timestamp":1790834850690,"version":"4.1.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec id=\"S0924270816000521_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Obsessive\u2013compulsive disorder (OCD) is a chronic psychiatric disorder leading to considerable distress and disability. Therapies are effective in a majority of paediatric patients, however, many only get partial response. It is therefore important to study the underlying pathophysiology of the disorder.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000521_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p><jats:sup>1<\/jats:sup>H magnetic resonance spectroscopy (MRS) was used to study the concentration of brain metabolites in four different locations (cingulate gyrus and sulcus, occipital cortex, thalamus and right caudate nucleus). Treatment-naive children and adolescents with OCD (13 subjects) were compared with a group of healthy age- and gender-matched subjects (11 subjects). Multivariate analyses were performed on the concentration values.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000521_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>No separation between controls and patients was found. However, a correlation between metabolite concentrations and symptom severity as measured with the Children\u2019s Yale-Brown Obsessive\u2013Compulsive Scale (CY-BOCS) was found. Strongest was the correlation with the CY-BOCS obsession subscore and aspartate and choline in the caudate nucleus (positively correlated with obsessions), lipids at 2 and 0.9 ppm in thalamus, and occipital glutamate+glutamine, <jats:italic>N<\/jats:italic>-acetylaspartate and myo-inosytol (negatively correlated with obsessions).<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000521_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The observed correlations between <jats:sup>1<\/jats:sup>H MRS and CY-BOCS in treatment-naive patients further supports an occipital involvement in OCD. The results are consistent with our previous study on adult OCD patients. The <jats:sup>1<\/jats:sup>H MRS data were not supportive of a separation between the patient and control groups.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2016.52","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T03:48:32Z","timestamp":1477280912000},"page":"179-190","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["<sup>1<\/sup>H magnetic resonance spectroscopy evidence for occipital involvement in treatment-naive paediatric obsessive\u2013compulsive disorder"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-2353","authenticated-orcid":false,"given":"Maria","family":"Ljungberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie K. 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