{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:54:03Z","timestamp":1789430043051,"version":"build-2803163510"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec id=\"S0924270816000594_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system may be a key factor in ASD. Here we investigated possible changes in the GABA system in rats exposed to a low dose of prenatal VPA.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000594_abs2\" sec-type=\"general\"><jats:title>Method<\/jats:title><jats:p>We performed autoradiography with [<jats:sup>3<\/jats:sup>H]muscimol, (a GABA<jats:sub>A<\/jats:sub> receptor agonist), and [<jats:sup>11<\/jats:sup>C]Ro15-4513 (a partial agonist of the GABA<jats:sub>A<\/jats:sub> \u03b1<jats:sub>1+5<\/jats:sub> receptor subtypes), in brain sections containing amygdala, thalamus and hippocampus of rats treated prenatally with 20 mg\/kg VPA or saline from the 12th day of gestation.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000594_abs3\" sec-type=\"general\"><jats:title>Result<\/jats:title><jats:p>Prenatal VPA significantly increased [<jats:sup>11<\/jats:sup>C]Ro15-4513 binding in the left amygdala compared with controls (<jats:italic>p<\/jats:italic>&lt;0.05). This difference was not observed in the hippocampus, thalamus or right amygdala. No differences were observed in [<jats:sup>3<\/jats:sup>H]muscimol binding.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270816000594_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>We observed an asymmetric increase in GABA<jats:sub>A<\/jats:sub> receptor binding. Disturbances in the GABA<jats:sub>A<\/jats:sub> receptor system have also been detected in human autism with [<jats:sup>11<\/jats:sup>C]Ro15-4513.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2016.59","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T08:12:52Z","timestamp":1481530372000},"page":"309-314","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Increased GABA<sub>A<\/sub> receptor binding in amygdala after prenatal administration of valproic acid to 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