{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:29:08Z","timestamp":1782908948032,"version":"3.54.5"},"reference-count":66,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec id=\"S0924270817000242_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270817000242_abs2\" sec-type=\"general\"><jats:title>Method<\/jats:title><jats:p>Male and female patients with schizophrenia (<jats:italic>n<\/jats:italic>=26) and adult ADHD (<jats:italic>n<\/jats:italic>=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (<jats:italic>n<\/jats:italic>=58) comprised the analysis set (<jats:italic>n<\/jats:italic>=108) of the total number of study participants (<jats:italic>n<\/jats:italic>=119). Coded sets of randomized ABR recordings were analysed by an independent party blinded to clinical diagnoses before a joint code-breaking session.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270817000242_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The ABR profiling test for schizophrenia identified schizophrenia patients versus controls with a sensitivity of 84.6% and a specificity of 93.1%. The ADHD test identified patients with adult ADHD versus controls with a sensitivity of 87.5% and a specificity of 91.4%.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270817000242_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The ABR profiling tests discriminated schizophrenia and ADHD versus healthy controls with high sensitivity and specificity. 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