{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:07:55Z","timestamp":1783649275873,"version":"3.55.0"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270818000133_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore effects of adjunctive treatment with <jats:italic>N<\/jats:italic>-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270818000133_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-\u03b1 (TNF-\u03b1), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270818000133_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-\u03b1 (TNF-\u03b1), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270818000133_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2018.13","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T07:54:56Z","timestamp":1531727696000},"page":"334-341","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Mediator effects of parameters of inflammation and neurogenesis from a <i>N<\/i>-acetyl cysteine clinical-trial for bipolar 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