{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:24:34Z","timestamp":1762507474558},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270818000170_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Our recent single-photon emission computed tomography (SPECT) study of patients with late-onset Alzheimer\u2019s disease (AD) revealed that regional cerebral blood flow (rCBF) was reduced in the frontal, temporal, and limbic lobes, and to a lesser degree in the parietal and occipital lobes. Moreover, these patients\u2019 scores on the Alzheimer\u2019s Disease Assessment Scale-cognitive subscale (ADAS-cog) were significantly correlated with rCBF in some gyri of the frontal, parietal, and limbic lobes. Our present study aimed to understand how vascular factors and metabolic disease influenced the relationship between rCBF and ADAS-cog scores.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270818000170_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We divided late-onset AD patients into two groups according to their Hachinski Ischemic Score (HIS), low vascular risk patients had values of \u22644 (<jats:italic>n<\/jats:italic>=25) and high vascular risk patients had scores \u22655 (<jats:italic>n<\/jats:italic>=15). We examined rCBF using brain perfusion SPECT data.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270818000170_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The degrees and patterns of reduced rCBF were largely similar between late-onset AD patients in both groups, regardless of HIS values. Cognitive function was significantly associated with rCBF among late-onset AD patients with low vascular risk (HIS\u22644), but not among those with high vascular risk (HIS\u22655). Furthermore, metabolic diseases, such as hypertension and diabetes mellitus, disrupted the relationships between hypoperfusion and cognitive impairments in late-onset AD patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270818000170_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Factors other than hypoperfusion, such as hypertension and diabetes mellitus, could be involved in the cognitive dysfunction of late-onset AD patients with high vascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2018.17","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T09:44:21Z","timestamp":1534931061000},"page":"350-358","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Vascular risk factors and the relationships between cognitive impairment and hypoperfusion in late-onset Alzheimer\u2019s 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