{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:30:36Z","timestamp":1790742636009,"version":"4.1.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"04","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S092427081900019X_as1\"><jats:title>Background:<\/jats:title><jats:p>Immune system markers may predict affective disorder treatment response, but whether an overall immune system marker predicts bipolar disorder treatment effect is unclear.<\/jats:p><\/jats:sec><jats:sec id=\"S092427081900019X_as2\"><jats:title>Methods:<\/jats:title><jats:p>Bipolar CHOICE (<jats:italic>N<\/jats:italic> = 482) and LiTMUS (<jats:italic>N<\/jats:italic> = 283) were similar comparative effectiveness trials treating patients with bipolar disorder for 24 weeks with four different treatment arms (standard-dose lithium, quetiapine, moderate-dose lithium plus optimised personalised treatment (OPT) and OPT without lithium). We performed secondary mixed effects linear regression analyses adjusted for age, gender, smoking and body mass index to investigate relationships between pre-treatment white blood cell (WBC) levels and clinical global impression scale (CGI) response.<\/jats:p><\/jats:sec><jats:sec id=\"S092427081900019X_as3\"><jats:title>Results:<\/jats:title><jats:p>Compared to participants with WBC counts of 4.5\u201310 \u00d7 10<jats:sup>9<\/jats:sup>\/l, participants with WBC &amp;lt; 4.5 or WBC \u2265 10 showed similar improvement within each specific treatment arm and in gender-stratified analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S092427081900019X_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>An overall immune system marker did not predict differential treatment response to four different treatment approaches for bipolar disorder all lasting 24 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2019.19","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T05:54:41Z","timestamp":1559800481000},"page":"230-234","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Correlation between white blood cell count and mood-stabilising treatment response in two bipolar disorder trials"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-1287","authenticated-orcid":false,"given":"Ole","family":"K\u00f6hler-Forsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa G.","family":"Sylvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Thase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin","family":"McInnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Tohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Kocsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence A.","family":"Ketter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward S.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Deckersbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ostacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan V.","family":"Iosifescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McElroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Nierenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"S092427081900019X_ref19","first-page":"22","volume":"59","author":"Sheehan","year":"1998","journal-title":"The Journal of Clinical Psychiatry"},{"key":"S092427081900019X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00123-6"},{"key":"S092427081900019X_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1740774509347399"},{"key":"S092427081900019X_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4048"},{"key":"S092427081900019X_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142382"},{"key":"S092427081900019X_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.08.003"},{"key":"S092427081900019X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.12.033"},{"key":"S092427081900019X_ref8","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.144"},{"key":"S092427081900019X_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2017.34"},{"key":"S092427081900019X_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12451"},{"key":"S092427081900019X_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0004867416644508"},{"key":"S092427081900019X_ref6","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14r09007"},{"key":"S092427081900019X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.12.023"},{"key":"S092427081900019X_ref5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.0_435.x"},{"key":"S092427081900019X_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.04.004"},{"key":"S092427081900019X_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12341"},{"key":"S092427081900019X_ref3","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05482yel"},{"key":"S092427081900019X_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.05.009"},{"key":"S092427081900019X_ref1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2013.0046"},{"key":"S092427081900019X_ref22","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07101560"},{"key":"S092427081900019X_ref21","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14010094"},{"key":"S092427081900019X_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/1740774513512184"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S092427081900019X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T06:14:25Z","timestamp":1563171265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S092427081900019X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":22,"journal-issue":{"issue":"04","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S092427081900019X"],"URL":"https:\/\/doi.org\/10.1017\/neu.2019.19","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]},"assertion":[{"value":"\u00a9 Scandinavian College of Neuropsychopharmacology 2019\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}