{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:41:16Z","timestamp":1780342876521,"version":"3.54.1"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270820000289_as1\"><jats:title>Objective:<\/jats:title><jats:p>Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex has been shown to have a statistically and clinically significant anti-depressant effect. The present pilot study was carried out to investigate if right prefrontal low-frequency rTMS as an add-on to electroconvulsive therapy (ECT) accelerates the anti-depressant effect and reduces cognitive side effects.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270820000289_as2\"><jats:title>Methods:<\/jats:title><jats:p>In this randomised, controlled, double-blind study, thirty-five patients with major depression were allocated to ECT+placebo or ECT+low-frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the major depression inventory (MDI). Furthermore, neuropsychological assessment of cognitive function was carried out.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270820000289_as3\"><jats:title>Results:<\/jats:title><jats:p>The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short-lived, and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270820000289_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>The addition of low-frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low-frequency rTMS could inhibit the anti-depressant effect of ECT.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2020.28","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T07:46:39Z","timestamp":1595835999000},"page":"328-338","source":"Crossref","is-referenced-by-count":6,"title":["Low-frequency rTMS inhibits the anti-depressive effect of ECT. 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