{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:42:23Z","timestamp":1753440143717,"version":"3.40.5"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270821000120_as1\"><jats:title>Objectives:<\/jats:title><jats:p>Identifying an objective, laboratory-based diagnostic tool (e.g. changes in gene expression), when used in conjunction with disease-specific clinical assessment, could increase the accuracy of the effectiveness of a therapeutic intervention.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270821000120_as2\"><jats:title>Methods:<\/jats:title><jats:p>We assessed the association between treatment outcome and blood RNA expression before the therapeutic intervention to post-treatment (after 1 year) of five autism spectrum disorder (ASD) toddlers who underwent an intensive cognitive-behavioural intervention integrated with psychomotor and speech therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270821000120_as3\"><jats:title>Results:<\/jats:title><jats:p>We found 113 significant differentially expressed genes enriched for the nervous system, immune system, and transcription and translation-related pathways. Some of these genes, as <jats:italic>MALAT-1<\/jats:italic>, <jats:italic>TSPO<\/jats:italic>, and <jats:italic>CFL1<\/jats:italic>, appear to be promising candidates.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270821000120_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Our findings show that changes in peripheral gene expression could be used in conjunction with clinical scales to monitor a rehabilitation intervention\u2019s effectiveness in toddlers affected by ASD. These results need to be validated in a larger cohort.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2021.12","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T10:39:59Z","timestamp":1619779199000},"page":"267-272","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Molecular biomarkers to track clinical improvement following an integrative treatment model in autistic toddlers"],"prefix":"10.1017","volume":"33","author":[{"given":"Ignazio S.","family":"Piras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Manti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Carone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Scalese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua S.","family":"Talboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Veronesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Tabolacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio M.","family":"Persico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Huentelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-8554","authenticated-orcid":false,"given":"Carla","family":"Lintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"S0924270821000120_ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00175"},{"key":"S0924270821000120_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192264"},{"key":"S0924270821000120_ref27","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.87"},{"key":"S0924270821000120_ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232351"},{"key":"S0924270821000120_ref14","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.4.457"},{"key":"S0924270821000120_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110376691"},{"key":"S0924270821000120_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28213"},{"key":"S0924270821000120_ref24","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.72"},{"key":"S0924270821000120_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2012.04.002"},{"key":"S0924270821000120_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114532"},{"key":"S0924270821000120_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.199"},{"key":"S0924270821000120_ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8127"},{"key":"S0924270821000120_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32511"},{"key":"S0924270821000120_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9462-8"},{"key":"S0924270821000120_ref13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3360-14.2014"},{"key":"S0924270821000120_ref15","first-page":"118","article-title":"Expression of Toll-Like Receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder","volume":"164","author":"K\u00e9ri","year":"2014","journal-title":"Brain, Behavior, and Immunity"},{"key":"S0924270821000120_ref22","first-page":"CD009260","article-title":"Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD)","volume":"5","author":"Reichow","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0924270821000120_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2016.1208841"},{"key":"S0924270821000120_ref20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118803109"},{"key":"S0924270821000120_ref2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"S0924270821000120_ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00483"},{"key":"S0924270821000120_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.06.042"},{"key":"S0924270821000120_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.10.010"},{"key":"S0924270821000120_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.030"},{"key":"S0924270821000120_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.017"},{"key":"S0924270821000120_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.01.012"},{"key":"S0924270821000120_ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093030"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270821000120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T11:41:41Z","timestamp":1641901301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270821000120\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0924270821000120"],"URL":"https:\/\/doi.org\/10.1017\/neu.2021.12","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"type":"print","value":"0924-2708"},{"type":"electronic","value":"1601-5215"}],"subject":[],"published":{"date-parts":[[2021,4,30]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}