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A total of 629 women (233 AN patients and 396 controls) were genotyped for 14 tag-SNPs. Psychometric evaluation was performed with the EDI-2 and SCL-90R questionnaires. Genetic associations were carried out by logistic regression controlling for age and adjusting for multiple comparisons (FDR method). Two tag-SNPs, rs11249969 and rs81442 (with a pairwise <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> value of 0.41), were associated with the global EDI-2 score, which measures EDI-related psychopathology (adjusted FDR-q = 0.02 and 0.04, respectively). Moreover, rs81442 significantly modulated all the scales of the SCL-90R test that evaluates general psychopathology (FDR-q values ranged from 4.1E-04 to 0.011). A sliding-window analysis using adjacent 3-SNP haplotypes revealed a proximal region of the <jats:italic>MSRA<\/jats:italic> gene spanning 187.8 Kbp whose variability deeply affected psychopathological symptoms of the AN patients. Depression was the symptom that showed the strongest association with any of the constructed haplotypes (FDR-<jats:italic>q<\/jats:italic> = 3.60E\u221206). No variants were found to be linked to AN risk or anthropometric parameters in patients or controls. Variability in the <jats:italic>MSRA<\/jats:italic> gene locus modulates psychopathology often presented by AN patients.<\/jats:p>","DOI":"10.1017\/neu.2021.24","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T09:09:30Z","timestamp":1629104970000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Variability in the antioxidant <i>MSRA<\/i> gene affects the psychopathology of patients with anorexia nervosa"],"prefix":"10.1017","volume":"33","author":[{"given":"Luz M","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angustias","family":"Garc\u00eda-Herr\u00e1iz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Mota-Zamorano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isalud","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-9767","authenticated-orcid":false,"given":"Guillermo","family":"Gervasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"S0924270821000247_ref46","first-page":"153","article-title":"Brain derived neurotrophic factor gene Val66Met and -270C\/T polymorphisms and personality traits predisposing to anorexia nervosa","volume":"28","author":"Rybakowski","year":"2007","journal-title":"Neuro Endocrinology Letters"},{"key":"S0924270821000247_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.02.035"},{"key":"S0924270821000247_ref21","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.77"},{"key":"S0924270821000247_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2017.e00349"},{"key":"S0924270821000247_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"S0924270821000247_ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00065"},{"key":"S0924270821000247_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.03.009"},{"key":"S0924270821000247_ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731660.x"},{"key":"S0924270821000247_ref36","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02883-8"},{"key":"S0924270821000247_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"S0924270821000247_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.305"},{"key":"S0924270821000247_ref12","unstructured":"Derogaitis, LR (2002) SCL-90R: Cuestionario de 90 s\u00edntomas. 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