{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:04:33Z","timestamp":1787868273048,"version":"build-2784847793"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270821000399_as1\"><jats:title>Background:<\/jats:title><jats:p>Neuroinflammation and brain structural abnormalities are found in bipolar disorder (BD). Elevated levels of cytokines and chemokines have been detected in the serum and cerebrospinal fluid of patients with BD. This study investigated the association between peripheral inflammatory markers and brain subregion volumes in BD patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270821000399_as2\"><jats:title>Methods:<\/jats:title><jats:p>Euthymic patients with bipolar I disorder (BD-I) aged 20\u201345 years underwent whole-brain magnetic resonance imaging. Plasma levels of monocyte chemoattractant protein-1 (MCP-1), chitinase-3-like protein 1 (also known as YKL-40), fractalkine (FKN), soluble tumour necrosis factor receptor-1 (sTNF-R1), interleukin-1\u03b2, and transforming growth factor-\u03b21 were measured on the day of neuroimaging. Clinical data were obtained from medical records and interviewing patients and reliable others.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270821000399_as3\"><jats:title>Results:<\/jats:title><jats:p>We recruited 31 patients with a mean age of 29.5 years. In multivariate regression analysis, plasma level YKL-40, a chemokine, was the most common inflammatory marker among these measurements displaying significantly negative association with the volume of various brain subareas across the frontal, temporal, and parietal lobes. Higher YKL-40 and sTNF-R1 levels were both significantly associated with lower volumes of the left anterior cingulum, left frontal lobe, right superior temporal gyrus, and supramarginal gyrus. A greater number of total lifetime mood episodes were also associated with smaller volumes of the right caudate nucleus and bilateral frontal lobes.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270821000399_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>The volume of brain regions known to be relevant to BD-I may be diminished in relation to higher plasma level of YKL-40, sTNF-R1, and more lifetime mood episodes. Macrophage and macrophage-like cells may be involved in brain volume reduction among BD-I patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2021.39","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T01:42:31Z","timestamp":1639964551000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Peripheral inflammatory markers associated with brain volume reduction in patients with bipolar I disorder"],"prefix":"10.1017","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-0055","authenticated-orcid":false,"given":"Shang-Ying","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Sajatovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Lung","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsuan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"S0924270821000399_ref21","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2766"},{"key":"S0924270821000399_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1967.tb00530.x"},{"key":"S0924270821000399_ref15","first-page":"195","article-title":"Interleukin-1\u03b2 in central nervous system injury and repair","volume":"1","author":"Hewett","year":"2012","journal-title":"European Journal of Neurodegenerative Disease"},{"key":"S0924270821000399_ref3","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.3\/mbelanger"},{"key":"S0924270821000399_ref30","unstructured":"Pan, WH (2019, July 12). 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