{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:29:22Z","timestamp":1783974562106,"version":"3.55.0"},"reference-count":64,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270822000205_as1\"><jats:title>Objectives:<\/jats:title><jats:p>To evaluate the impact of genetic deletion of receptors of the counterregulatory arms of the renin\u2013angiotensin system in depressive-like behaviours.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270822000205_as2\"><jats:title>Methods:<\/jats:title><jats:p>8\u201312 weeks-old male mice wild type (WT, C57BL\/6J) and mice with genetic deletion of MrgD (MrgD KO) or Mas receptors (Mas KO) were subjected to the Forced Swim Test (FST) and the Tail Suspension Test (TST). Brain-derived neurotrophic factor (BDNF) levels were measured by enzyme-linked immunosorbent assay (ELISA). Blockade of Mas was performed by acute intracerebroventricular (<jats:italic>icv<\/jats:italic>) injection of its selective antagonist, A779.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270822000205_as3\"><jats:title>Results:<\/jats:title><jats:p>No statistical difference in immobility time was observed between MrgD KO and WT male animals subjected to FST and TST. However, acute <jats:italic>icv<\/jats:italic> injection of A779 significantly increased the immobility time of MrgD KO male mice subjected to FST and TST, suggesting the involvement of Mas in preventing depressive-like behaviour. Indeed, Mas KO male animals showed increased immobility time in FST and TST, evidencing a depressive-like behaviour in these animals, in addition to a reduction in BDNF levels in the prefrontal cortex and hippocampus. No changes in BDNF levels were observed in MrgD KO male animals.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270822000205_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Our data showed that Mas plays an important role in the neurobiology of depression probably by modulating BDNF expression. On the contrary, lack of MrgD did not alter depressive-like behaviour, which was supported by the lack of alterations in BDNF levels.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2022.20","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T08:57:13Z","timestamp":1660813033000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice"],"prefix":"10.1017","volume":"35","author":[{"given":"Luca","family":"Becari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza A.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sth\u00e9fanie C. 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